4-氨基-5-己烯酸盐酸盐
| 中文名称 | 4-氨基-5-己烯酸盐酸盐 |
|---|---|
| 中文同义词 | 4-氨基-5-己烯酸盐酸盐;盐酸氨己烯酸;VIGABATRIN(中间体);氨己烯酸盐酸盐 |
| 英文名称 | Vigabatrin (Hydrochloride) |
| 英文同义词 | Vigabatrin (Hydrochloride);Vigabatrin HCL;4-Amino-5-hexenoic acid hydrochloride (1:1);4-aminohex-5-enoic acid hydrochloride;Γ-VINYL-GABA HYDROCHLORIDE;SABRIL HYDROCHLORIDE;Vigabatrin 13C D2 HClQ: What is Vigabatrin 13C D2 HCl Q: What is the CAS Number of Vigabatrin 13C D2 HCl Q: What are the applications of Vigabatrin 13C D2 HCl;γ-Vinyl-GABA hydrochloride |
| CAS号 | 1391054-02-6 |
| 分子式 | C6H12ClNO2 |
| 分子量 | 165.61798 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;Inhibitors |
| Mol文件 | 1391054-02-6.mol |
| 结构式 |  |
4-氨基-5-己烯酸盐酸盐 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 颜色 | 灰白色至浅棕色 |
| 稳定性 | 吸湿性 |
A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin.
Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-B0033 | Vigabatrin hydrochloride | 5 mg | 500元 | |
| 2024/04/30 | HY-B0033 | 4-氨基-5-己烯酸盐酸盐 Vigabatrin hydrochloride | 1391054-02-6 | 10mg | 800元 |