双环霉素苯酸盐
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- CAS号:
- 37134-40-0
- 英文名:
- BicozaMycin benzoate, FR 2054
- 英文别名:
- FR2054;BicycloMycin benzoate;Bicyclomycin benzoate,FR 2054;BicozaMycin benzoate, FR 2054;Bicyclomycin, 3'-benzoate (9CI);(2S,3S)-2,3-dihydroxy-3-((1S,6R)-6-hydroxy-5-methylene-8,10-dioxo-2-oxa-7,9-diazabicyclo[4.2.2]decan-1-yl)-2-methylpropyl benzoate
- 中文名:
- 双环霉素苯酸盐
- 中文别名:
- 双环霉素苯甲酸;双环霉素苯酸盐;双环霉素苯甲酸酯;化合物 T10541;化合物 BICYCLOMYCIN BENZOATE
- CBNumber:
- CB22703705
- 分子式:
- C19H22N2O8
- 分子量:
- 406.39
- MOL File:
- 37134-40-0.mol
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双环霉素苯酸盐化学性质
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熔点:
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>123°C (dec.)
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沸点:
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788.6±60.0 °C(Predicted)
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密度:
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1.49±0.1 g/cm3(Predicted)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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9.82±0.60(Predicted)
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颜色:
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White
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双环霉素苯酸盐性质、用途与生产工艺
Bicyclomycin benzoate是一种广谱的抑制革兰氏阴性细菌和革兰氏阳性细菌的抗生素。
The primary action of bicyclomycin is due to interference with the biosynthesis of lipoprotein and its assembly to peptidoglycan in the cell envelope of
E. coli
. At the lethal level, bicyclomycin is shown to inhibit the synthesis of RNA and protein in the growing cells of
E. coli
15 THU. Bicyclomycin targets the rho transcription termination factor in
Escherichia coli
. Bicyclomycin is a modest rho inhibitor, can disrupt the rho molecular machinery thereby leading to a catastrophic effect caused by the untimely overproduction of proteins not normally expressed constitutively, thus leading to a toxic effect on the cells. The inhibition of rho poly(C)-stimulated hydrolysis of ATP by bicyclomycin has been found to proceed by a non-competitive, reversible pathway with respect to ATP (K
i
=20 μM).
Bicyclomycin has low excretion rate after a single intramuscular dose of 50 mg/kg in rats. Bicyclomycin is well distributed in various tissues, and the highest concentration is observed in the kidney at 100 mg/kg.
双环霉素苯酸盐
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-101128 | 双环霉素苯酸盐 Bicyclomycin benzoate | 37134-40-0 | 5mg | 1100元 |
2024/08/19 | HY-101128 | 双环霉素苯酸盐 Bicyclomycin benzoate | 37134-40-0 | 10mM * 1mLin DMSO | 1210元 |
37134-40-0, 双环霉素苯酸盐 相关搜索:
- 抑制剂
- 微生物代谢物
- 化合物 BICYCLOMYCIN BENZOATE
- 双环霉素苯甲酸酯
- 双环霉素苯甲酸
- 化合物 T10541
- 双环霉素苯酸盐
- 37134-40-0
- (2S,3S)-2,3-dihydroxy-3-((1S,6R)-6-hydroxy-5-methylene-8,10-dioxo-2-oxa-7,9-diazabicyclo[4.2.2]decan-1-yl)-2-methylpropyl benzoate
- Bicyclomycin, 3'-benzoate (9CI)
- FR2054
- Bicyclomycin benzoate,FR 2054
- BicycloMycin benzoate
- BicozaMycin benzoate, FR 2054