双环霉素苯酸盐
中文名称 | 双环霉素苯酸盐 |
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中文同义词 | 双环霉素苯酸盐;化合物 T10541;双环霉素苯甲酸;双环霉素苯甲酸酯 |
英文名称 | BicozaMycin benzoate, FR 2054 |
英文同义词 | BicozaMycin benzoate, FR 2054;BicycloMycin benzoate;Bicyclomycin benzoate,FR 2054;FR2054;Bicyclomycin, 3'-benzoate (9CI);(2S,3S)-2,3-dihydroxy-3-((1S,6R)-6-hydroxy-5-methylene-8,10-dioxo-2-oxa-7,9-diazabicyclo[4.2.2]decan-1-yl)-2-methylpropyl benzoate |
CAS号 | 37134-40-0 |
分子式 | C19H22N2O8 |
分子量 | 406.39 |
EINECS号 | |
相关类别 | 微生物代谢物 |
Mol文件 | 37134-40-0.mol |
结构式 |
双环霉素苯酸盐 性质
熔点 | >123°C (dec.) |
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沸点 | 788.6±60.0 °C(Predicted) |
密度 | 1.49±0.1 g/cm3(Predicted) |
储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 9.82±0.60(Predicted) |
颜色 | 白色 |
The primary action of bicyclomycin is due to interference with the biosynthesis of lipoprotein and its assembly to peptidoglycan in the cell envelope of E. coli . At the lethal level, bicyclomycin is shown to inhibit the synthesis of RNA and protein in the growing cells of E. coli 15 THU. Bicyclomycin targets the rho transcription termination factor in Escherichia coli . Bicyclomycin is a modest rho inhibitor, can disrupt the rho molecular machinery thereby leading to a catastrophic effect caused by the untimely overproduction of proteins not normally expressed constitutively, thus leading to a toxic effect on the cells. The inhibition of rho poly(C)-stimulated hydrolysis of ATP by bicyclomycin has been found to proceed by a non-competitive, reversible pathway with respect to ATP (K i =20 μM).
Bicyclomycin has low excretion rate after a single intramuscular dose of 50 mg/kg in rats. Bicyclomycin is well distributed in various tissues, and the highest concentration is observed in the kidney at 100 mg/kg.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101128 | 双环霉素苯酸盐 Bicyclomycin benzoate | 37134-40-0 | 5mg | 1100元 |
2024/04/30 | HY-101128 | 双环霉素苯酸盐 Bicyclomycin benzoate | 37134-40-0 | 10mM * 1mLin DMSO | 1210元 |