865285-29-6
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- CAS号:
- 865285-29-6
- 英文名:
- 4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide
- 英文别名:
- KKL-35;SRJ-23;KKL-35
(KKL 35;KKL-35 >=98% (HPLC);KKL35,Bacterial,Inhibitor,KKL 35,inhibit,KKL-35;4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide;Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-
- 中文名:
- 865285-29-6
- 中文别名:
- 化合物KKL-35;4-氯-N-(5-(4-氟苯基)-1,3,4-恶二唑-2-基)苯甲酰胺
- CBNumber:
- CB22750608
- 分子式:
- C15H9ClFN3O2
- 分子量:
- 317.7
- MOL File:
- 865285-29-6.mol
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865285-29-6化学性质
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble5mg/mL, clear (warmed)
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形态:
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powder
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颜色:
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white to beige
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865285-29-6性质、用途与生产工艺
KKL-35抑制trans-translation tagging reaction,IC50为0.9 μM。它具有广谱抗生素活性。
IC50: 0.9 µM (
trans
-translation tagging reaction)
KKL-35 exhibits broad-spectrum antibiotic activity. KKL-35 prevents growth of
B. anthracis
and
M. smegmatis
with minimum inhibitory concentration (MIC) values of less than 6 µM. KKL-35 inhibit trans-translation at some step before proteolysis of tagged proteins. KKL-35 inhibits tagging of DHFR-ns. A large amount of untagged DHFR is produced in reactions with the highest concentrations of KKL-35, indicating that KKL-35 does not inhibit translation. KKL-35 prevents growth of WT
S. flexneri
with a MIC of 6 µM, and addition of KKL-35 to a growing culture of
S. flexneri
stops growth. In an
S. flexneri
strain expressing ArfA and deleted for ssrA, addition of KKL-35 has little effect on viability or growth rate. KKL-35 inhibits the growth of
E. coli
∆tolC, which is deficient in small molecule efflux, with an MIC of 0.3 µM.
Evidence suggest that the
in vivo
effects of KKL-35 are caused by inhibition of the release of nonstop translation complexes by trans-translation. KKL-35 inhibits trans-translation and prevents growth of S. flexneri strains that require trans-translation. The correlation between inhibition of trans-translation and growth is supported by genetic and pharmacological experiments showing that alternative mechanisms to release nonstop translation complexes relieve the growth suppression of KKL-35.
865285-29-6
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-101866 | 865285-29-6 KKL-35 | 865285-29-6 | 5mg | 1275元 |
2024/04/30 | HY-101866 | KKL-35 | | 25 mg | 4200元 |
865285-29-6, 865285-29-6 相关搜索:
- 药靶配体
- 化合物KKL-35
- 4-氯-N-(5-(4-氟苯基)-1,3,4-恶二唑-2-基)苯甲酰胺
- 865285-29-6
- KKL35,Bacterial,Inhibitor,KKL 35,inhibit,KKL-35
- SRJ-23
- KKL-35
(KKL 35
- Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-
- KKL-35 >=98% (HPLC)
- KKL-35
- 4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide