865285-29-6
中文名称 | 865285-29-6 |
---|---|
中文同义词 | 4-氯-N-(5-(4-氟苯基)-1,3,4-恶二唑-2-基)苯甲酰胺;化合物KKL-35 |
英文名称 | 4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide |
英文同义词 | 4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide;KKL-35;KKL-35 >=98% (HPLC);Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-;KKL-35 (KKL 35;SRJ-23;KKL35,Bacterial,Inhibitor,KKL 35,inhibit,KKL-35 |
CAS号 | 865285-29-6 |
分子式 | C15H9ClFN3O2 |
分子量 | 317.7 |
EINECS号 | |
相关类别 | |
Mol文件 | 865285-29-6.mol |
结构式 | ![]() |
865285-29-6 性质
储存条件 | Sealed in dry,2-8°C |
---|---|
溶解度 | DMSO:可溶5mg/mL,澄清(加热) |
形态 | 粉末 |
颜色 | 白色至米色 |
IC50: 0.9 µM ( trans -translation tagging reaction)
KKL-35 exhibits broad-spectrum antibiotic activity. KKL-35 prevents growth of B. anthracis and M. smegmatis with minimum inhibitory concentration (MIC) values of less than 6 µM. KKL-35 inhibit trans-translation at some step before proteolysis of tagged proteins. KKL-35 inhibits tagging of DHFR-ns. A large amount of untagged DHFR is produced in reactions with the highest concentrations of KKL-35, indicating that KKL-35 does not inhibit translation. KKL-35 prevents growth of WT S. flexneri with a MIC of 6 µM, and addition of KKL-35 to a growing culture of S. flexneri stops growth. In an S. flexneri strain expressing ArfA and deleted for ssrA, addition of KKL-35 has little effect on viability or growth rate. KKL-35 inhibits the growth of E. coli ∆tolC, which is deficient in small molecule efflux, with an MIC of 0.3 µM.
Evidence suggest that the in vivo effects of KKL-35 are caused by inhibition of the release of nonstop translation complexes by trans-translation. KKL-35 inhibits trans-translation and prevents growth of S. flexneri strains that require trans-translation. The correlation between inhibition of trans-translation and growth is supported by genetic and pharmacological experiments showing that alternative mechanisms to release nonstop translation complexes relieve the growth suppression of KKL-35.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-101866 | 865285-29-6 KKL-35 | 865285-29-6 | 5mg | 1275元 |
2024/04/30 | HY-101866 | KKL-35 | 25 mg | 4200元 |