化合物MAO-IN-M30二盐酸盐
|
|
|
- CAS号:
- 64821-19-8
- 英文名:
- VAR10300 dihydrochloride
- 英文别名:
- M30 dihydrochloride;M-30 dihydrochloride;VAR10300 dihydrochloride;MAO-IN-M30 dihydrochloride;5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride;5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride;N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride
- 中文名:
- 化合物MAO-IN-M30二盐酸盐
- 中文别名:
- M 30 二盐酸盐;化合物MAO-IN-M30二盐酸盐
- CBNumber:
- CB22750653
- 分子式:
- C14H15ClN2O
- 分子量:
- 262.74
- MOL File:
- 64821-19-8.mol
|
|
|
化合物MAO-IN-M30二盐酸盐化学性质
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMSO, heptane and xylene: ≥21mg/mL
-
|
-
形态:
-
powder
-
|
-
颜色:
-
green-yellow
-
|
-
水溶解性:
-
Soluble to 100 mM in water
-
|
化合物MAO-IN-M30二盐酸盐性质、用途与生产工艺
MAO-IN-M30 dihydrochloride 是一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
|
MAO-A
37 nM (IC
50
)
|
MAO-B
57 nM (IC
50
)
|
MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone.
MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.
MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells.
Cell Viability Assay
|
Cell Line:
|
SH-SY5Y cells
|
|
Concentration:
|
0.25 nM
|
|
Incubation Time:
|
72 hours
|
|
Result:
|
Significantly increased cell viability to ∼90% after exposure to Dexamethasone.
|
Cell Viability Assay
|
Cell Line:
|
PC12 cells
|
|
Concentration:
|
0-10 μM
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%.
|
MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities.
|
Animal Model:
|
Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)
|
|
Dosage:
|
0.5, 2.5 mg/kg
|
|
Administration:
|
P.o.; once daily for 14 consecutive days
|
|
Result:
|
Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.
|
化合物MAO-IN-M30二盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-131036 | MAO-IN-M30 dihydrochloride | | 1 mg | 480元 |
| 2024/04/30 | HY-131036 | MAO-IN-M30 dihydrochloride | 64821-19-8 | 5mg | 1000元 |
64821-19-8, 化合物MAO-IN-M30二盐酸盐 相关搜索:
- 酶
- M 30 二盐酸盐
- 化合物MAO-IN-M30二盐酸盐
- 64821-19-8
- MAO-IN-M30 dihydrochloride
- 5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride
- N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride
- VAR10300 dihydrochloride
- M-30 dihydrochloride
- M30 dihydrochloride
- 5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride