化合物MAO-IN-M30二盐酸盐

化合物MAO-IN-M30二盐酸盐

中文名称化合物MAO-IN-M30二盐酸盐
中文同义词化合物MAO-IN-M30二盐酸盐;M 30 二盐酸盐
英文名称VAR10300 dihydrochloride
英文同义词5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride;M30 dihydrochloride;M-30 dihydrochloride;VAR10300 dihydrochloride;N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride;5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride;MAO-IN-M30 dihydrochloride
CAS号64821-19-8
分子式C14H15ClN2O
分子量262.74
EINECS号
相关类别
Mol文件64821-19-8.mol
结构式化合物MAO-IN-M30二盐酸盐 结构式

化合物MAO-IN-M30二盐酸盐 性质

储存条件2-8°C
溶解度DMSO、庚烷和二甲苯:≥21mg/mL
形态粉末
颜色黄绿色
水溶解性Soluble to 100 mM in water

化合物MAO-IN-M30二盐酸盐 用途与合成方法

MAO-IN-M30 dihydrochloride 是一种口服活性,可通过血脑屏障的,脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。

MAO-A

37 nM (IC 50 )

MAO-B

57 nM (IC 50 )

MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone.
MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.
MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells.

Cell Viability Assay

Cell Line: SH-SY5Y cells
Concentration: 0.25 nM
Incubation Time: 72 hours
Result: Significantly increased cell viability to ∼90% after exposure to Dexamethasone.

Cell Viability Assay

Cell Line: PC12 cells
Concentration: 0-10 μM
Incubation Time: 24 hours
Result: Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%.

MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities.

Animal Model: Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)
Dosage: 0.5, 2.5 mg/kg
Administration: P.o.; once daily for 14 consecutive days
Result: Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.

安全信息

危险品标志Xn
危险类别码22-41
安全说明26-39
WGK Germany3

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/04/30HY-131036MAO-IN-M30 dihydrochloride1 mg480元
2024/04/30HY-131036MAO-IN-M30 dihydrochloride64821-19-85mg1000元

化合物MAO-IN-M30二盐酸盐 上下游产品信息

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