化合物MAO-IN-M30二盐酸盐
中文名称 | 化合物MAO-IN-M30二盐酸盐 |
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中文同义词 | 化合物MAO-IN-M30二盐酸盐;M 30 二盐酸盐 |
英文名称 | VAR10300 dihydrochloride |
英文同义词 | 5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride;M30 dihydrochloride;M-30 dihydrochloride;VAR10300 dihydrochloride;N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride;5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride;MAO-IN-M30 dihydrochloride |
CAS号 | 64821-19-8 |
分子式 | C14H15ClN2O |
分子量 | 262.74 |
EINECS号 | |
相关类别 | |
Mol文件 | 64821-19-8.mol |
结构式 |
化合物MAO-IN-M30二盐酸盐 性质
储存条件 | 2-8°C |
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溶解度 | DMSO、庚烷和二甲苯:≥21mg/mL |
形态 | 粉末 |
颜色 | 黄绿色 |
水溶解性 | Soluble to 100 mM in water |
MAO-A 37 nM (IC 50 ) |
MAO-B 57 nM (IC 50 ) |
MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone.
MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.
MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells.
Cell Viability Assay
Cell Line: | SH-SY5Y cells |
Concentration: | 0.25 nM |
Incubation Time: | 72 hours |
Result: | Significantly increased cell viability to ∼90% after exposure to Dexamethasone. |
Cell Viability Assay
Cell Line: | PC12 cells |
Concentration: | 0-10 μM |
Incubation Time: | 24 hours |
Result: | Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%. |
MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities.
Animal Model: | Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice) |
Dosage: | 0.5, 2.5 mg/kg |
Administration: | P.o.; once daily for 14 consecutive days |
Result: | Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-131036 | MAO-IN-M30 dihydrochloride | 1 mg | 480元 | |
2024/04/30 | HY-131036 | MAO-IN-M30 dihydrochloride | 64821-19-8 | 5mg | 1000元 |