化合物MAO-IN-M30二盐酸盐
| 中文名称 | 化合物MAO-IN-M30二盐酸盐 |
|---|---|
| 中文同义词 | 化合物MAO-IN-M30二盐酸盐;M 30 二盐酸盐 |
| 英文名称 | VAR10300 dihydrochloride |
| 英文同义词 | 5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride;M30 dihydrochloride;M-30 dihydrochloride;VAR10300 dihydrochloride;N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride;5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride;MAO-IN-M30 dihydrochloride |
| CAS号 | 64821-19-8 |
| 分子式 | C14H15ClN2O |
| 分子量 | 262.74 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 64821-19-8.mol |
| 结构式 |  |
化合物MAO-IN-M30二盐酸盐 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO、庚烷和二甲苯：≥21mg/mL |
| 形态 | 粉末 |
| 颜色 | 黄绿色 |
| 水溶解性 | Soluble to 100 mM in water |
MAO-IN-M30 dihydrochloride 是一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
|
MAO-A 37 nM (IC 50 ) |
MAO-B 57 nM (IC 50 ) |
MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone.
MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.
MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells.
Cell Viability Assay
| Cell Line: | SH-SY5Y cells |
| Concentration: | 0.25 nM |
| Incubation Time: | 72 hours |
| Result: | Significantly increased cell viability to ∼90% after exposure to Dexamethasone. |
Cell Viability Assay
| Cell Line: | PC12 cells |
| Concentration: | 0-10 μM |
| Incubation Time: | 24 hours |
| Result: | Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%. |
MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities.
| Animal Model: | Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice) |
| Dosage: | 0.5, 2.5 mg/kg |
| Administration: | P.o.; once daily for 14 consecutive days |
| Result: | Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-131036 | MAO-IN-M30 dihydrochloride | 1 mg | 480元 | |
| 2024/04/30 | HY-131036 | MAO-IN-M30 dihydrochloride | 64821-19-8 | 5mg | 1000元 |