WWL113
|
|
|
- CAS号:
- 947669-86-5
- 英文名:
- WWL113
- 英文别名:
- WWL113;WWL-113,WWL113;AKIIPHDGVCFVCC-UHFFFAOYSA-N;ethyl 4-[4-[methyl-[(3-pyridin-4-ylphenyl)methyl]carbamoyl]oxyphenyl]benzoate;4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester;[1,1'-Biphenyl]-4-carboxylic acid, 4'-[[[methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-, ethyl ester
- 中文名:
- WWL113
- 中文别名:
- 化合物 T17259
- CBNumber:
- CB23067596
- 分子式:
- C29H26N2O4
- 分子量:
- 466.52774
- MOL File:
- 947669-86-5.mol
|
|
|
WWL113化学性质
-
沸点:
-
630.9±55.0 °C(Predicted)
-
|
-
密度:
-
1?+-.0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.1 mg/ml
-
|
-
形态:
-
A crystalline solid
-
|
-
酸度系数(pKa):
-
5.18±0.26(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
WWL113性质、用途与生产工艺
WWL113 是具有口服活性的、选择性的 Ces3 和 Ces1f 的抑制剂，其对 Ces3 和 Ces1f 的 IC50 值分别为 120 nM 和 100 nM。WWL113 对 60-kDa丝氨酸水解酶(或水解酶)有极好的选择性。
IC50: 120 nM (Ces3), 100 nM (Ces1f).
Ces3 and Ces1f are endoplasmic reticulum glycoproteins that have been previously associated with adipocyte lipolysis. WWL113 inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM.
WWL113 (1 μM) significantly increases UCP1 protein expression in brown adipocytes.
WWL113 has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2.
WWL113 (30 mg/kg, orally once a day) results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance.
WWL113 ameliorates obesity-diabetes in mice.
|
Animal Model:
|
Eight-week-old db/db mice (n = 10 per group).
|
|
Dosage:
|
30 mg/kg.
|
|
Administration:
|
Orally once a day for 3 weeks.
|
|
Result:
|
Corrected multiple features of metabolic syndrome in db/db mice.
|
WWL113
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-110148 | WWL113
WWL113 | 947669-86-5 | 5 mg | 800元 |
| 2024/04/30 | HY-110148 | WWL113 | | 10 mM * 1 mLin DMSO | 820元 |
947669-86-5, WWL113 相关搜索:
- 化合物 T17259
- 947669-86-5
- [1,1'-Biphenyl]-4-carboxylic acid, 4'-[[[methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-, ethyl ester
- WWL-113,WWL113
- 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
- ethyl 4-[4-[methyl-[(3-pyridin-4-ylphenyl)methyl]carbamoyl]oxyphenyl]benzoate
- AKIIPHDGVCFVCC-UHFFFAOYSA-N
- WWL113