WWL113
| 中文名称 | WWL113 |
|---|---|
| 中文同义词 | 化合物 T17259 |
| 英文名称 | WWL113 |
| 英文同义词 | WWL113;AKIIPHDGVCFVCC-UHFFFAOYSA-N;ethyl 4-[4-[methyl-[(3-pyridin-4-ylphenyl)methyl]carbamoyl]oxyphenyl]benzoate;4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester;WWL-113,WWL113;[1,1'-Biphenyl]-4-carboxylic acid, 4'-[[[methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-, ethyl ester |
| CAS号 | 947669-86-5 |
| 分子式 | C29H26N2O4 |
| 分子量 | 466.52774 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 947669-86-5.mol |
| 结构式 |  |
WWL113 性质
| 沸点 | 630.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1?+-.0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：25mg/mL； DMF:PBS(pH7.2)(1:2)：0.3mg/ml； DMSO：15mg/mL；乙醇：0.1mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 5.18±0.26(Predicted) |
| 颜色 | 白色至米白色 |
IC50: 120 nM (Ces3), 100 nM (Ces1f).
Ces3 and Ces1f are endoplasmic reticulum glycoproteins that have been previously associated with adipocyte lipolysis. WWL113 inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM.
WWL113 (1 μM) significantly increases UCP1 protein expression in brown adipocytes.
WWL113 has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2.
WWL113 (30 mg/kg, orally once a day) results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance.
WWL113 ameliorates obesity-diabetes in mice.
| Animal Model: | Eight-week-old db/db mice (n = 10 per group). |
| Dosage: | 30 mg/kg. |
| Administration: | Orally once a day for 3 weeks. |
| Result: | Corrected multiple features of metabolic syndrome in db/db mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-110148 | WWL113 WWL113 | 947669-86-5 | 5 mg | 800元 |
| 2024/04/30 | HY-110148 | WWL113 | 10 mM * 1 mLin DMSO | 820元 |