947669-91-2
中文名称 | 947669-91-2 |
---|---|
中文同义词 | 化合物WWL70;4'-氨基甲酰基-[1,1'-联苯]-4-基 甲基(3-(吡啶-4-基)苄基)氨基甲酸酯;WWL 70,ABHD6抑制剂;WWL70 化学试剂 |
英文名称 | WWL70 |
英文同义词 | WWL70;N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-ylcarbamicacidester;4-CARBAMOYL-[1,1-BIPHENYL]-4-YL METHYL(3-(PYRIDIN-4-YL)BENZYL)CARBAMATE;WWL 70; WWL70; WWL-70.;[4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate;Carbamic acid, N-methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-, 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester;Inhibitor,MAGL,Monoacylglycerol lipase,WWL70,WWL 70,inhibit,WWL-70 |
CAS号 | 947669-91-2 |
分子式 | C27H23N3O3 |
分子量 | 437.49 |
EINECS号 | |
相关类别 | 标准品 |
Mol文件 | 947669-91-2.mol |
结构式 |
947669-91-2 性质
储存条件 | Store at +4°C |
---|---|
溶解度 | DMSO : 17.33 mg/mL (39.61 mM; 需要超声波)H2O : < 0.1 mg/mL (不溶) |
形态 | 粉末 |
IC50: 70 nM (ABHD6)
At 1 h after WWL70 (10 μM) treatment, 2-Arachidonoylglycerol (2-AG) is increased by 20% compare to untreated cells. At either 1 or 10 μM, WWL70 completely blocks the lipopolysaccharide (LPS)-induced increase of PGE 2 . The enhanced mRNA expression of mPGES-1 and mPGES-2 by LPS is also reduced by WWL70. The IC 50 of WWL70 to inhibit the PGE 2 biosynthesis is about 100 nM.
Although post-treatment with WWL70 at 5 mg/kg does not have any effect, treatment with WWL70 at 10 mg/kg improves the performance significantly. WWL70 treatment improves motor coordination of traumatic brain injury (TBI) mice in a concentration dependent manner. The latency to fall in animals treated with WWL70 at 5 mg/kg increases from 74.92±4.8 to 99.57±5.21 on day 3 (p<0.01) and from 87.32±4.42 to 100.14±3.56 on day 7 (p<0.05) post-injury when compare with the vehicle-TBI groups. At 10 mg/kg, WWL70 treatment improves motor coordination starting on day 1 post-injury. WWL70 treatment completely restores the ability of TBI mice to continuously alternate arms during Y maze exploration (69.67±4.98 %).
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-100337 | WWL70 | 1 mg | 450元 | |
2024/04/30 | HY-100337 | 947669-91-2 WWL70 | 947669-91-2 | 5mg | 990元 |