929895-45-4
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- CAS号:
- 929895-45-4
- 英文名:
- Phen-DC3 Trifluoromethanesulfonate
- 英文别名:
- Phen-DC3 Triflate;Phen-DC3 Trifluoromethanesulfonate
- 中文名:
- 929895-45-4
- 中文别名:
- 化合物 T13817L;解旋酶FANCJ和DING抑制剂
- CBNumber:
- CB23386507
- 分子式:
- C36H26F6N6O8S2
- 分子量:
- 848.7474592
- MOL File:
- 929895-45-4.mol
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929895-45-4化学性质
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熔点:
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>260 °C(Solv: ethyl ether (60-29-7))
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 34 mg/mL (40.06 mM)
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形态:
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Solid
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颜色:
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White to light yellow
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929895-45-4性质、用途与生产工艺
Phen-DC3 Trifluoromethanesulfonate 是一个 G4 特异性配体，可以抑制解旋酶 FANCJ 和 DinG 且 IC50s 值分别为 65±6 和 50±10 nM。
IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)
In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remaines fully stable in both PIF1-treated and WT cells.
929895-45-4
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-15594A | 929895-45-4
Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 1mg | 600元 |
| 2024/08/19 | HY-15594A | 929895-45-4
Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 5mg | 1035元 |
929895-45-4, 929895-45-4 相关搜索:
- 试剂
- 细胞生物学试剂
- 化合物 T13817L
- 解旋酶FANCJ和DING抑制剂
- 929895-45-4
- Phen-DC3 Trifluoromethanesulfonate
- Phen-DC3 Triflate