Phen-DC3 Trifluoromethanesulfonate
- CAS No.
- 929895-45-4
- Chemical Name:
- Phen-DC3 Trifluoromethanesulfonate
- Synonyms
- Phen-DC3 Triflate;Phen-DC3 Trifluoromethanesulfonate
- CBNumber:
- CB23386507
- Molecular Formula:
- C36H26F6N6O8S2
- Molecular Weight:
- 848.7474592
- MDL Number:
- MFCD32067401
- MOL File:
- 929895-45-4.mol
Phen-DC3 Trifluoromethanesulfonate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-7711 | Phen-DC3Trifluoromethanesulfonate 99.53% | 929895-45-4 | 1mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-7711 | Phen-DC3Trifluoromethanesulfonate 99.53% | 929895-45-4 | 5mg | $540 | 2021-12-16 | Buy |
| ChemScene | CS-7711 | Phen-DC3Trifluoromethanesulfonate 99.53% | 929895-45-4 | 10mg | $900 | 2021-12-16 | Buy |
| ChemScene | CS-7711 | Phen-DC3Trifluoromethanesulfonate 99.53% | 929895-45-4 | 50mg | $2700 | 2021-12-16 | Buy |
Phen-DC3 Trifluoromethanesulfonate Chemical Properties,Uses,Production
Biological Activity
Phen-DC3 Trifluoromethanesulfonate is a G4-specific ligand that inhibits the helicases FANCJ and DinG with IC50s of 65±6 and 50±10 nM, respectively.
in vitro
In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remains fully stable in both PIF1-treated and WT cells.
target
IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)
Phen-DC3 Trifluoromethanesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
Phen-DC3 Trifluoromethanesulfonate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9772 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-020-82000279 18988968278 | sales@ubiochem.com | China | 4297 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29802 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5012 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9268 | 58 |