3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐
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- CAS号:
- 147388-83-8
- 英文名:
- ABT-418 HYDROCHLORIDE
- 英文别名:
- ABT-418 HCl;ABT-418 HYDROCHLORIDE;ABT418 hydrochloride,ABT 418 hydrochloride;(S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazolea€￠HCl;3-Methyl-5-[(2S)-1-Methylpyrrolidin-2-yl]isoxazole hydrochloride;3-Methyl-5-[(2S)-1-Methyl-2-Pyrrolidinyl]-1,2-Oxazole Hydrochloride
- 中文名:
- 3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐
- 中文别名:
- 化合物 T10224;3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐
- CBNumber:
- CB2497879
- 分子式:
- C9H14N2O.ClH
- 分子量:
- 202.684
- MOL File:
- 147388-83-8.mol
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3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐化学性质
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储存条件:
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-20°C
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溶解度:
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H2O: 15 mg/mL, soluble
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形态:
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solid
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颜色:
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white to off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
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3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐性质、用途与生产工艺
ABT-418 hydrochloride 是一种高效、选择性的 nAChRs 激动剂，具有增强认知和抗焦虑的作用。ABT-418 hydrochloride 激活胆碱能通道，可用于阿尔茨海默病的研究。
ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze.
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment.
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD.
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression.
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Animal Model:
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Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model
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Dosage:
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0.6 mg/kg
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Administration:
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Intraperitoneal injection; once daily; for two weeks
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Result:
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Effectively improved spatial memory.
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3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-105170B | ABT-418 hydrochloride | | 1 mg | 545元 |
| 2024/08/19 | HY-105170B | 3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐
ABT-418 hydrochloride | 147388-83-8 | 5mg | 1200元 |
3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐
生产厂家
147388-83-8, 3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐 相关搜索:
- 化合物 T10224
- 3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐
- 147388-83-8
- 3-Methyl-5-[(2S)-1-Methyl-2-Pyrrolidinyl]-1,2-Oxazole Hydrochloride
- ABT418 hydrochloride,ABT 418 hydrochloride
- (S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazolea€￠HCl
- 3-Methyl-5-[(2S)-1-Methylpyrrolidin-2-yl]isoxazole hydrochloride
- ABT-418 HYDROCHLORIDE
- ABT-418 HCl