ABT-418 HYDROCHLORIDE
- CAS No.
- 147388-83-8
- Chemical Name:
- ABT-418 HYDROCHLORIDE
- Synonyms
- ABT-418 HCl;ABT-418 HYDROCHLORIDE;ABT418 hydrochloride,ABT 418 hydrochloride;(S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazolea€￠HCl;3-Methyl-5-[(2S)-1-Methylpyrrolidin-2-yl]isoxazole hydrochloride;3-Methyl-5-[(2S)-1-Methyl-2-Pyrrolidinyl]-1,2-Oxazole Hydrochloride
- CBNumber:
- CB2497879
- Molecular Formula:
- C9H14N2O.ClH
- Molecular Weight:
- 202.684
- MDL Number:
- MFCD11045960
- MOL File:
- 147388-83-8.mol
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| solubility | H2O: 15 mg/mL, soluble |
| form | solid |
| color | white to off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| FDA UNII | 1ALA933VO4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330 |
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 22-28-36/37-45-7/9 |
| RIDADR | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
ABT-418 HYDROCHLORIDE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A6476 | ABT-418 hydrochloride powder, ≥98% (HPLC) | 147388-83-8 | 5mg | $282 | 2024-03-01 | Buy |
| Sigma-Aldrich | A6476 | ABT-418 hydrochloride powder, ≥98% (HPLC) | 147388-83-8 | 25mg | $776 | 2024-03-01 | Buy |
| TRC | A112610 | ABT-418 hydrochloride | 147388-83-8 | 5mg | $165 | 2021-12-16 | Buy |
| TRC | A112610 | ABT-418 hydrochloride | 147388-83-8 | 10mg | $265 | 2021-12-16 | Buy |
| ChemScene | CS-0025191 | ABT-418 hydrochloride 99.53% | 147388-83-8 | 5mg | $120 | 2021-12-16 | Buy |
ABT-418 HYDROCHLORIDE Chemical Properties,Uses,Production
Description
ABT-418 (CAS 147388-83-8) is an agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat model and was 6-fold more potent than diazepam.2 Reduces distractibility in a primate model3 and may have relevance in attention deficit hyperactivity disorder4. Improves cognition in Alzheimer’s disease patients.5
Uses
ABT-418 Hydrochloride is a neuronal nicotinic acetylcholine receptor agonist or activator which can be synthesized from L-proline.
References
1) Papke et al. (1997), Activation and inhibition of rat neuronal nicotinic receptors by ABT-418; Br. J. Pharmacol., 120 429 2) Brioni et al. (1994), Anxiolytic-like effects of the novel cholinergic channel activator ABT-418; J. Pharmacol. Exp. Therap., 271 353 3) Prendergast et al. (1998), Central nicotinic receptor agonists ABT-418, ABT089, and (-)-nicotine reduce distractibility in adult monkey; Psychopharmacology (Berl), 136 50 4) Beiderman and Spencer (2000), Non-stimulant treatments for ADHD; Eur. Child Adolesc. Psychiatry, 9 Suppl1 151 5) Potter et al. (1999), Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer’s disease; Psychopharmacology (Berl), 142 334
ABT-418 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ABT-418 HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| Shanghai Anhua Biotechnology Co., Ltd. | 021-61263375 18168859245 | China | 5958 | 58 | |
| Wuxi maimo topp biotechnology co., LTD | 15061806929 | linda-fu@mimotopes.cn | China | 5849 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |