Β-AMINOARTEETHER
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- CAS号:
- 133162-24-0
- 英文名:
- Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]-
- 英文别名:
- SM934 free base;β-Aminoarteether;Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]-
- 中文名:
- Β-AMINOARTEETHER
- 中文别名:
- 化合物Β-AMINOARTEETHER
- CBNumber:
- CB28359317
- 分子式:
- C17H29NO5
- 分子量:
- 327.42
- MOL File:
- 133162-24-0.mol
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Β-AMINOARTEETHER化学性质
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沸点:
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421.0±45.0 °C(Predicted)
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密度:
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1.20±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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8.46±0.10(Predicted)
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Β-AMINOARTEETHER性质、用途与生产工艺
β-Aminoarteether (SM934 free base) 是一种具有口服活性的 Artemisinin 衍生物。β-Aminoarteether 可用于炎症和自身免疫性疾病的研究，例如狼疮疾病。
β-Aminoarteether (SM934;10 µM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation.
In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation.
β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice.
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Animal Model:
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Female NZB/W F1 mice (Six and half months old)
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Dosage:
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1 mg/kg, 3 mg/kg, and 10 mg/kg
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Administration:
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Oral administration; daliy; for 3 months
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Result:
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Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice.
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Β-AMINOARTEETHER
上下游产品信息
上游原料
下游产品
133162-24-0, Β-AMINOARTEETHER 相关搜索:
- 化合物Β-AMINOARTEETHER
- 133162-24-0
- SM934 free base
- β-Aminoarteether
- Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]-