Β-AMINOARTEETHER
中文名称 | Β-AMINOARTEETHER |
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中文同义词 | 化合物Β-AMINOARTEETHER |
英文名称 | Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]- |
英文同义词 | Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]-;β-Aminoarteether;SM934 free base |
CAS号 | 133162-24-0 |
分子式 | C17H29NO5 |
分子量 | 327.42 |
EINECS号 | |
相关类别 | |
Mol文件 | 133162-24-0.mol |
结构式 | ![]() |
Β-AMINOARTEETHER 性质
沸点 | 421.0±45.0 °C(Predicted) |
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密度 | 1.20±0.1 g/cm3(Predicted) |
酸度系数(pKa) | 8.46±0.10(Predicted) |
β-Aminoarteether (SM934;10 µM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation.
In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation.
β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice.
Animal Model: | Female NZB/W F1 mice (Six and half months old) |
Dosage: | 1 mg/kg, 3 mg/kg, and 10 mg/kg |
Administration: | Oral administration; daliy; for 3 months |
Result: | Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice. |