A2TI-1
|
|
|
- CAS号:
- 570390-00-0
- 英文名:
- Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-
- 英文别名:
- A2ti-1;Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-
- 中文名:
- A2TI-1
- 中文别名:
- CBNumber:
- CB28379540
- 分子式:
- C20H22N4O2S
- 分子量:
- 382.48
- MOL File:
- 570390-00-0.mol
|
|
|
A2TI-1化学性质
-
沸点:
-
642.4±65.0 °C(Predicted)
-
|
-
密度:
-
1.26±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 250 mg/mL (653.63 mM)
-
|
-
酸度系数(pKa):
-
15.06±0.40(Predicted)
-
|
A2TI-1性质、用途与生产工艺
A2ti-1 是选择性的，高亲和力的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂，IC50 为 24 μM。A2ti-1 特异性破坏 A2 和 S100A10 之间的蛋白质相互作用。A2ti-1 可防止人乳头瘤病毒 16 型 (HPV16) 感染。
A2ti-1 (compound 1 b) is an annexin A2-S100A10 protein-protein interaction blocker.
A2ti-1 (100 μM; for 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner.
A2ti-1 (10, 25, 50, 75, 100 μM; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner.
Cell Viability Assay
|
Cell Line:
|
HeLa cells
|
|
Concentration:
|
100 μM
|
|
Incubation Time:
|
For 72 hours
|
|
Result:
|
Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells.
|
A2TI-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-136465 | A2ti-1 | 570390-00-0 | 5mg | 2333元 |
| 2024/04/30 | HY-136465 | A2ti-1 | 570390-00-0 | 10mM * 1mLin DMSO | 2566元 |
570390-00-0, A2TI-1 相关搜索:
- 570390-00-0
- A2ti-1
- Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-