A2TI-1
| 中文名称 | A2TI-1 |
|---|---|
| 中文同义词 | |
| 英文名称 | Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]- |
| 英文同义词 | Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-;A2ti-1 |
| CAS号 | 570390-00-0 |
| 分子式 | C20H22N4O2S |
| 分子量 | 382.48 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 570390-00-0.mol |
| 结构式 |  |
A2TI-1 性质
| 沸点 | 642.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/ml（653.63 mM） |
| 酸度系数(pKa) | 15.06±0.40(Predicted) |
A2ti-1 是选择性的，高亲和力的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂，IC50 为 24 μM。A2ti-1 特异性破坏 A2 和 S100A10 之间的蛋白质相互作用。A2ti-1 可防止人乳头瘤病毒 16 型 (HPV16) 感染。
IC50: 24 μM (A2t)
A2ti-1 (compound 1 b) is an annexin A2-S100A10 protein-protein interaction blocker.
A2ti-1 (100 μM; for 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner.
A2ti-1 (10, 25, 50, 75, 100 μM; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner.
Cell Viability Assay
| Cell Line: | HeLa cells |
| Concentration: | 100 μM |
| Incubation Time: | For 72 hours |
| Result: | Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-136465 | A2ti-1 | 570390-00-0 | 5mg | 2333元 |
| 2024/04/30 | HY-136465 | A2ti-1 | 570390-00-0 | 10mM * 1mLin DMSO | 2566元 |