占托西林
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- CAS号:
- 580-74-5
- 英文名:
- Xantocillin
- 英文别名:
- Brevicid;Nsc179485;Brevicide;Trianthil;Brevicide-x;Xantocillin;Ophthocillin;XANTHOCILINX;XANTHOCILLINX;Ethylene isocyanide, bis(p-hydroxybenzylidene)-
- 中文名:
- 占托西林
- 中文别名:
- 占托西林;黄青霉素;青黴黃素X;化合物 T17261
- CBNumber:
- CB31180074
- 分子式:
- C18H12N2O2
- 分子量:
- 0
- MOL File:
- 580-74-5.mol
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占托西林化学性质
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沸点:
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430.53°C (rough estimate)
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密度:
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1.2396 (rough estimate)
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折射率:
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1.5800 (estimate)
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占托西林性质、用途与生产工艺
Xanthocillin 是从青霉中提取的一种海洋药剂，通过抑制 MEK/ERK 途径诱导自噬。
Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 µM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC
50
of 22.88 ± 4.76 µM.
Xantocillin (SD118-xanthocillin X (1)) (24.3 µM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1.
Cell Proliferation Assay
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Cell Line:
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HepG2 cells
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Concentration:
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6.9 µM, 13.89 µM, 27.78 µM, 55.56 µM
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Incubation Time:
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48 hours
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Result:
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A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC
50
of 22.88 ± 4.76 µM.
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Western Blot Analysis
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Cell Line:
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HepG2 cells
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Concentration:
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24.3 µM
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Incubation Time:
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12 hours, 24 hours, 48 hours
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Result:
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Increased the expression of the autophagy-related genes, LC3, and Beclin 1.
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占托西林
上下游产品信息
上游原料
下游产品
580-74-5, 占托西林 相关搜索:
- 抑制剂
- 化合物 T17261
- 黄青霉素
- 青黴黃素X
- 占托西林
- 580-74-5
- Trianthil
- Phenol, 4,4'-(2,3-diisocyano-1,3-butadiene-1,4-diyl)bis-
- Ophthocillin
- Nsc179485
- Ethylene isocyanide, bis(p-hydroxybenzylidene)-
- Brevicide-x
- Brevicide
- Brevicid
- 1,4-Di-p-oxyphenyl-2,3-di-isonitrilo-1,3-butadien
- 4,4'-(2,3-Diisocyano-1,3-butadiene-1,4-diyl)bisphenol
- Xantocillin
- XANTHOCILINX
- XANTHOCILLINX