4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐
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- CAS号:
- 99247-33-3
- 英文名:
- PROGLUMIDE, SODIUM SALT
- 英文别名:
- PROGLUMIDE SODIUM;PROGLUMIDE, SODIUM SALT;Proglumide sodium salt solid;PROGLUMIDE SODIUM SALT SELECTIVE CHOLECY STOK;4-benzamido-5-(dipropylamino)-5-oxopentanoate;dl-4-benzamido-n,n-dipropylglutaramicacidsodiumsalt;SODIUM;4-BENZAMIDO-5-(DIPROPYLAMINO)-5-OXOPENTANOATE;4-benzamido-n,n-dipropyl-,sodiumsalt,dl-glutaramicaci;4-BENZOYLAMINO-5-DIPROPYLAMINO-5-OXOPENTANOIC ACID SODIUM;Glutaramic acid, 4-benzamido-N,N-dipropyl-, sodium salt, DL-
- 中文名:
- 4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐
- 中文别名:
- 丙谷胺钠;丙谷胺 钠盐;化合物 T23185;4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐;4-苯甲酰胺基-5-(二丙基氨基)-5-氧代戊酸钠
- CBNumber:
- CB3125814
- 分子式:
- C18H27N2NaO4
- 分子量:
- 358.41
- MOL File:
- 99247-33-3.mol
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4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐化学性质
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储存条件:
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Desiccate at RT
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溶解度:
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H2O: soluble
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形态:
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solid
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颜色:
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white
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水溶解性:
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Soluble to 100 mM in water
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4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐性质、用途与生产工艺
Proglumide sodium 是一种非肽和口服活性胆囊收缩素 (CCK)-A/B 受体拮抗剂。Proglumide sodium 选择性阻断 CCK 在中枢神经系统中的作用。Proglumide sodium 具有抑制胃分泌和保护胃十二指肠粘膜的能力，还具有抗癫痫和抗氧化活性。
Cholecystokinin (CCK)-A/B receptors
In an in vitro study, Proglumide at concentrations between 0.3-10 mM inhibits CCK-stimulated amylase release dose-dependently, while Proglumide does not influence the basal amylase release at concentrations between 0-3 mM. Dose-response curves to CCK for amylase release shifted to the right with increase in Proglumide concentration. This inhibition by Proglumide is reversible. In addition, the effect of Proglumide is selective for CCK and its related peptide.
The incubation of HT29 cells with Proglumide significantly reduces the [
3
H]-thymidine incorporation to HT29 cells in a dose-dependent manner, with an IC
50
of 6.5 mM. Proglumide reduces in a dose-dependent manner the percentage of necrosis with a parallel increase of apoptosis up to 70%.
Proglumide (250-750 mg/kg; intraperitoneal injection; adult male Sprague Dawley rats) treatment is significantly effective in ameliorating the seizure activities, cognitive dysfunctions, and cerebral oxidative stress.
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Animal Model:
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Adult male Sprague Dawley rats (200-250 g; 2 months old) are induced status epilepticus (SE)
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Dosage:
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250 mg/kg, 500 mg/kg, and 750 mg/kg
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Administration:
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Intraperitoneal injection
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Result:
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Dose-dependently and significantly increased the latencies to seizure and SE. Significantly and dose-dependently attenuated Li-PC (SE) induced increase in thiobarbituric acid (TBARS) and catalase (CAT), attenuated Li-Pc induced decrease in SOD, and attenuated depletion of GSH and glutathione-S transferase (GST) in the hippocampus and striatum.
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4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-103354 | 4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐
Proglumide sodium | 99247-33-3 | 50mg | 600元 |
| 2024/08/19 | HY-103354 | 4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐
Proglumide sodium | 99247-33-3 | 10mM * 1mLin Water | 660元 |
4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐
生产厂家
99247-33-3, 4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐 相关搜索:
- 抑制剂
- 药靶配体
- C18H25N2O4Na
- C18H25N2NaO4
- 4-苯甲酰胺基-5-(二丙基氨基)-5-氧代戊酸钠
- 丙谷胺 钠盐
- 化合物 T23185
- 丙谷胺钠
- 4-苯酰胺-5-二丙氨基-5-氧戊酸钠盐
- 99247-33-3
- Proglumide sodium salt solid
- 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
- 4-benzamido-5-(dipropylamino)-5-oxopentanoate
- SODIUM;4-BENZAMIDO-5-(DIPROPYLAMINO)-5-OXOPENTANOATE
- N-Benzoyl-N′,N′-dipropyl-DL-isoglutamine sodium-potassium salt
- Glutaramic acid, 4-benzamido-N,N-dipropyl-, sodium salt, DL-
- N-Benzoyl-Nμ,Nμ-dipropyl-DL-isoglutamine sodium-potassium salt, 4-Benzoylamino-5-dipropylamino-5-oxopentanoic acid sodium-potassium salt
- 4-benzoylamino-5-dipropylamino-5-oxopentanoic acid sodium-potassium salt
- PROGLUMIDE SODIUM SALT SELECTIVE CHOLECY STOK
- pentanoicacid,4-(benzoylamino)-5-(dipropylamino)-5-oxo-,monosodiumsalt,(
- dl-4-benzamido-n,n-dipropylglutaramicacidsodiumsalt
- 4-benzamido-n,n-dipropyl-,sodiumsalt,dl-glutaramicaci
- PROGLUMIDE, SODIUM SALT
- PROGLUMIDE SODIUM
- 4-BENZOYLAMINO-5-DIPROPYLAMINO-5-OXOPENTANOIC ACID SODIUM
- DL-4-(BENZOYLAMINO)-5-(DIPROPYLAMINO)-5-OXOPENTANOIC ACID, NA