142606-55-1
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- CAS号:
- 142606-55-1
- 英文名:
- p2Ca peptide
- 英文别名:
- p2Ca;p2Ca peptide;H-Leu-Ser-Pro-Phe-Pro-Phe-Asp-Leu-OH;L-Leucine, L-leucyl-L-seryl-L-prolyl-L-phenylalanyl-L-prolyl-L-phenylalanyl-L-α-aspartyl-
- 中文名:
- 142606-55-1
- 中文别名:
- CBNumber:
- CB31359889
- 分子式:
- C47H66N8O12
- 分子量:
- 935.07
- MOL File:
- 142606-55-1.mol
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142606-55-1化学性质
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沸点:
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1307.2±65.0 °C(Predicted)
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密度:
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1.298±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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3.24±0.10(Predicted)
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水溶解性:
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Soluble in Water
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142606-55-1性质、用途与生产工艺
p2Ca是8聚体肽,是天然加工并呈递给Ld同种异体T细胞克隆2C的配体。
p2Ca and QL9 peptides assume distinct conformations when bind to Ld and, furthermore, demonstrate that there is flexibility in peptide binding within the MHC class I cleft. Ld antigenic peptide p2Ca (LSPFPFDL) is 8-mer that lack the proline at position 2 and thus use alternative amino-terminal anchors. The p2Ca octamer is identified as the ligand that is naturally processed and presented to the Ld-alloreactive T cell clone, 2C. p2Ca, is immunodominant in allorecognition of the murine MHC class I molecule H-2Ld. The majority of Ld-alloreactive T-cell clones are specific for Ld-p2Ca and this immunodominance is not due to peptide cross-reactivity. p2Ca is a ubiquitously expressed self-peptide. p2Ca is derived from the mouse mitochondrial enzyme α-ketoglutarate dehydrogenase. p2Ca is present in every tissue of BALB/c mice that has been examined, including the spleen and thymus. It is also expressed by mouse tumor cell lines such as the mastocytoma P815. CTL derived
in vitro
recognize specifically the p2Ca/L d complex and use Vβ8 regions predominantly. The cultured cells lyse target cells with lower levels of p2Ca than the levels used for induction. This result suggests that it may be possible to use peptides at high concentrations to elicit CTL that react with endogenous levels of a peptide/class I complex.
BALB/c mice, coinjected with a syngeneic BALB/c myeloma and exogenous p2Ca, are able to reject the tumor. The p2Ca/L d system may thus provide a model for evaluating the parameters for effective immunotherapy with tumor-associated peptides.
142606-55-1
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2023/03/20 | HY-P0260 | 142606-55-1 p2Ca | 142606-55-1 | 1mg | 2200元 |
2023/03/20 | HY-P0260 | 142606-55-1 p2Ca | 142606-55-1 | 5mg | 8000元 |
142606-55-1, 142606-55-1 相关搜索:
- C47H66N8O12
- 142606-55-1
- L-Leucine, L-leucyl-L-seryl-L-prolyl-L-phenylalanyl-L-prolyl-L-phenylalanyl-L-α-aspartyl-
- H-Leu-Ser-Pro-Phe-Pro-Phe-Asp-Leu-OH
- p2Ca
- p2Ca peptide