142606-55-1

142606-55-1

中文名称142606-55-1
中文同义词
英文名称p2Ca peptide
英文同义词p2Ca peptide;p2Ca;H-Leu-Ser-Pro-Phe-Pro-Phe-Asp-Leu-OH;L-Leucine, L-leucyl-L-seryl-L-prolyl-L-phenylalanyl-L-prolyl-L-phenylalanyl-L-α-aspartyl-
CAS号142606-55-1
分子式C47H66N8O12
分子量935.07
EINECS号
相关类别
Mol文件142606-55-1.mol
结构式142606-55-1 结构式

142606-55-1 性质

沸点1307.2±65.0 °C(Predicted)
密度1.298±0.06 g/cm3(Predicted)
储存条件Store at -20°C
酸度系数(pKa)3.24±0.10(Predicted)
水溶解性Soluble in Water

142606-55-1 用途与合成方法

p2Ca是8聚体肽,是天然加工并呈递给Ld同种异体T细胞克隆2C的配体。

p2Ca and QL9 peptides assume distinct conformations when bind to Ld and, furthermore, demonstrate that there is flexibility in peptide binding within the MHC class I cleft. Ld antigenic peptide p2Ca (LSPFPFDL) is 8-mer that lack the proline at position 2 and thus use alternative amino-terminal anchors. The p2Ca octamer is identified as the ligand that is naturally processed and presented to the Ld-alloreactive T cell clone, 2C. p2Ca, is immunodominant in allorecognition of the murine MHC class I molecule H-2Ld. The majority of Ld-alloreactive T-cell clones are specific for Ld-p2Ca and this immunodominance is not due to peptide cross-reactivity. p2Ca is a ubiquitously expressed self-peptide. p2Ca is derived from the mouse mitochondrial enzyme α-ketoglutarate dehydrogenase. p2Ca is present in every tissue of BALB/c mice that has been examined, including the spleen and thymus. It is also expressed by mouse tumor cell lines such as the mastocytoma P815. CTL derived in vitro recognize specifically the p2Ca/L d complex and use Vβ8 regions predominantly. The cultured cells lyse target cells with lower levels of p2Ca than the levels used for induction. This result suggests that it may be possible to use peptides at high concentrations to elicit CTL that react with endogenous levels of a peptide/class I complex.

BALB/c mice, coinjected with a syngeneic BALB/c myeloma and exogenous p2Ca, are able to reject the tumor. The p2Ca/L d system may thus provide a model for evaluating the parameters for effective immunotherapy with tumor-associated peptides.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2023/03/20HY-P0260142606-55-1
p2Ca
142606-55-11mg2200元
2023/03/20HY-P0260142606-55-1
p2Ca
142606-55-15mg8000元

142606-55-1 上下游产品信息

"142606-55-1"相关产品信息
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