CP 465022 HYDROCHLORIDE
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- CAS号:
- 199655-36-2
- 英文名:
- 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
- 英文别名:
- CP465022HCl;CP465022; CP-465022;CP 465022 hydrochlor;CP 465022 hydrochloride;3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone;4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-;3-(2-chlorophenyl)-2-(2-6-[(diethylamino)methyl]pyridin-2-ylethenyl)-6-fluoro-3,4-dihydroquinazolin-4-one;3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride;(E)-3-(2-chlorophenyl)-2-(2-(6-((diethylamino)methyl)pyridin-2-yl)vinyl)-6-fluoroquinazolin-4(3H)-one hydrochloride;CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
- 中文名:
- CP 465022 HYDROCHLORIDE
- 中文别名:
- CP 465022盐酸盐;CP 465022游离的;3-(2-氯苯基)-2-[2-[6-[(二乙基氨基)甲基]-2-吡啶基]乙烯基]-6-氟-4(3H)喹唑啉酮
- CBNumber:
- CB32518843
- 分子式:
- C26H24ClFN4O
- 分子量:
- 462.95
- MOL File:
- 199655-36-2.mol
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CP 465022 HYDROCHLORIDE化学性质
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沸点:
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585.0±60.0 °C(Predicted)
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密度:
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1.23±0.1 g/cm3(Predicted)
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储存条件:
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Desiccate at RT
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溶解度:
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insoluble in H2O; <49.94mg/ml in DMSO
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形态:
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solid
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酸度系数(pKa):
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8.51±0.25(Predicted)
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颜色:
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Yellow
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CP 465022 HYDROCHLORIDE性质、用途与生产工艺
CP-465022 hydrochloride 是一种强效的、选择性的、非竞争性的 AMPA受体 拮抗剂，具有抗惊厥活性。CP-465022 对 Kainate 诱导反应具有抑制作用，IC50 为 25 nM。CP-465022 是研究 AMPA 受体在生理和病理方面研究的有效工具。
IC50: 25 nM (rat cortical neurons)
CP-465022 (0.0001 μM-10 μM) inhibits kainate-induced response in relatively slow manner and dependents on compound concentration, exhibiting a calculated IC
50
of 25 nM and essentially complete inhibition at 3.2 µM.
CP-465022 1 µM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 µM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons.
CP-465022 1 µM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons.CP-465022 (100 nM -10 µM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 µM CP-465,022 nearly complete inhibits this time frame (99.3%).
CP 465022 HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2023/03/20 | HY-18663B | CP 465022 HYDROCHLORIDE
CP-465022 hydrochloride | 199655-36-2 | 5 mg | 6900元 |
| 2023/03/20 | HY-18663B | CP 465022 HYDROCHLORIDE
CP-465022 hydrochloride | 199655-36-2 | 10 mg | 11000元 |
CP 465022 HYDROCHLORIDE
生产厂家
199655-36-2, CP 465022 HYDROCHLORIDE 相关搜索:
- 药靶配体
- 对照品
- C26H24ClFN4OHCl
- C26H24ClFN4O
- CP 465022盐酸盐
- CP 465022游离的
- 3-(2-氯苯基)-2-[2-[6-[(二乙基氨基)甲基]-2-吡啶基]乙烯基]-6-氟-4(3H)喹唑啉酮
- 199655-36-2
- 3-(2-chlorophenyl)-2-(2-6-[(diethylamino)methyl]pyridin-2-ylethenyl)-6-fluoro-3,4-dihydroquinazolin-4-one
- (E)-3-(2-chlorophenyl)-2-(2-(6-((diethylamino)methyl)pyridin-2-yl)vinyl)-6-fluoroquinazolin-4(3H)-one hydrochloride
- CP 465022 hydrochlor
- 4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-
- CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
- 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone
- CP465022; CP-465022
- CP465022HCl
- CP 465022 hydrochloride
- 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride