3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
![3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Structure](CAS/GIF/199655-36-2.gif)
- CAS No.
- 199655-36-2
- Chemical Name:
- 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
- Synonyms
- CP465022HCl;CP465022; CP-465022;CP 465022 hydrochlor;CP 465022 hydrochloride;3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone;4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-;3-(2-chlorophenyl)-2-(2-6-[(diethylamino)methyl]pyridin-2-ylethenyl)-6-fluoro-3,4-dihydroquinazolin-4-one;3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride;(E)-3-(2-chlorophenyl)-2-(2-(6-((diethylamino)methyl)pyridin-2-yl)vinyl)-6-fluoroquinazolin-4(3H)-one hydrochloride;CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
- CBNumber:
- CB32518843
- Molecular Formula:
- C26H24ClFN4O
- Molecular Weight:
- 462.95
- MDL Number:
- MOL File:
- 199655-36-2.mol
3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Properties
| Boiling point | 585.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at RT |
| solubility | insoluble in H2O; <49.94mg/ml in DMSO |
| form | solid |
| pka | 8.51±0.25(Predicted) |
| color | Yellow |
| FDA UNII | 4582JTR93Y |
3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2932 | CP465022hydrochloride ≥99%(HPLC) | 199655-36-2 | 10 | $184 | 2021-12-16 | Buy |
| Tocris | 2932 | CP465022hydrochloride ≥99%(HPLC) | 199655-36-2 | 50 | $785 | 2021-12-16 | Buy |
| Usbiological | 255038 | CP 465022 hydrochloride | 199655-36-2 | 10mg | $423 | 2021-12-16 | Buy |
| TRC | P398988 | CP465022 | 199655-36-2 | 50mg | $1260 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009992 | CP 465022 HYDROCHLORIDE 95.00% | 199655-36-2 | 10MG | $716.1 | 2021-12-16 | Buy |
3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Chemical Properties,Uses,Production
Uses
CP 465022 is an AMPA antagonist.
Biological Activity
cp 465022 hydrochloride is a potent and selective antagonist of ampa receptor with ic50 value of 25 nm [1].the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampa receptor) is an ionotropic transmembrane receptor for glutamate and mediates fast synaptic transmission in the central nervous system. ampa receptors are oligomeric assemblies of four protein subunits, glur1-4.cp 465022 hydrochloride is a noncompetitive and selective ampa receptor antagonist. in rat cortical neurons, cp-465022 inhibited currents induced by kainate (100 μm) with ic50 value of 25 nm and completely inhibited at concentration up to 3.2 μm. in hnt human teratocarcinoma cells, cp-465022 inhibited kainate-induced currents with ic50 value of 15 nm, which was mediated by ampa receptors. in cultured cortical neurons stimulated by kainate, cp-465022 dose-dependently inhibited kainate-induced responses by 54% and 88% at 10 nm and 100 nm, respectively [1]. in hek cells expressing the nav1.6 channel, cp465022 dose-dependently inhibited nav1.6-mediated persistent current [2].in rats after stimulation of schaeffer collateral/commissural pathway, cp-465022 reversibly inhibited the evoked population spike amplitude in the ca1 region. in pentylenetetrazole-induced seizure rats, cp-465022 dose-dependently reduced the incidence of tonic seizures, clonic seizures and lethality. cp-465022 inhibited vertical and horizontal locomotor activity with ed50 values of 6.6 and 11.9 mg/kg, respectively [3].
storage
Room temperature (desiccate)
References
[1]. lazzaro jt, paternain av, lerma j, et al. functional characterization of cp-465,022, a selective, noncompetitive ampa receptor antagonist. neuropharmacology, 2002, 42(2): 143-153.
[2]. welch nc, lin w, juranka pf, et al. traditional ampa receptor antagonists partially block na v1.6-mediated persistent current. neuropharmacology, 2008, 55(7): 1165-1171.
[3]. menniti fs, buchan am, chenard bl, et al. cp-465,022, a selective noncompetitive ampa receptor antagonist, blocks ampa receptors but is not neuroprotective in vivo. stroke, 2003, 34(1): 171-176.
3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29826 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Tianjin Derchemist Science & Technology Co., Ltd. | 22-58627059 13920586291 | zdcomcon@126.com | China | 3166 | 50 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3717 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8010 | 62 |
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2019-12-31 | 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
199655-36-2
|
US $1.00 / KG | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
199655-36-2
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co