KONGENSIN A
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- CAS号:
- 885315-96-8
- 英文名:
- Kongensin A
- 英文别名:
- Kongensin A;7,10-Methano-7H-benzocycloundecene-8,13-dione, 1-(acetyloxy)-1,2,3,4,4a,5,6,9,10,11,12,13a-dodecahydro-6-hydroxy-4,4,13a-trimethyl-9-methylene-, (1R,4aR,6R,10R,13aS)-
- 中文名:
- KONGENSIN A
- 中文别名:
- 化合物 T5136;化合物 KONGENSIN A
- CBNumber:
- CB32519820
- 分子式:
- C22H30O5
- 分子量:
- 374.4706
- MOL File:
- 885315-96-8.mol
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KONGENSIN A化学性质
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熔点:
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160-162 °C(Solv: chloroform (67-66-3))
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沸点:
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525.7±50.0 °C(Predicted)
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密度:
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1.17±0.1 g/cm3(Predicted)
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储存条件:
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4°C, protect from light
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形态:
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Solid
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酸度系数(pKa):
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13.07±0.70(Predicted)
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颜色:
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White to light yellow
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KONGENSIN A性质、用途与生产工艺
Kongensin A 是一种从 Croton kongensis 中分离的天然产物。 Kongensin A 是一种有效的，共价的 HSP90 抑制剂，可阻断 RIP3 依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂，并具有潜在的抗坏死性和消炎性应用。
Kongensin A (0-15 μM; 6 hours; HT29 cells) treatment induces caspase activation and apoptosis in multiple cancer cell lines in a dosage-dependent manner.
Kongensin A (0-15 μM; 24 hours; HT29 cells) treatment induces the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induces the up-regulation of HSP90A and HSP90B.
Kongensin A covalently binds to cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37. The HSP90-CDC37 complex is required for RIP3 activation, KA blocks LPS/Smac mimetics/Z-VAD and RIP3 polymerization-induced cell death, in which cell death is dependent on RIP3 but not its upstream kinase RIP1.
Apoptosis Analysis
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Cell Line:
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HT29 cells
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Concentration:
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0 μM, 2.5 μM, 5 μM, 15 μM
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Incubation Time:
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6 hours
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Result:
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Induced caspase activation and apoptosis in a dosage-dependent manner.
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Western Blot Analysis
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Cell Line:
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HT29 cells
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Concentration:
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0 μM, 2.5 μM, 5 μM, 15 μM
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Incubation Time:
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24 hours
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Result:
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Induced the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induced the up-regulation of HSP90A and HSP90B.
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KONGENSIN A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/11/08 | HY-N3417 | KONGENSIN A
Kongensin A | 885315-96-8 | 1 mg | 9500元 |
| 2023/03/20 | HY-N3417 | KONGENSIN A
Kongensin A | 885315-96-8 | 5 mg | 20800元 |
885315-96-8, KONGENSIN A 相关搜索:
- 抑制剂
- 二萜
- 植物提取物
- 化合物 KONGENSIN A
- 化合物 T5136
- 885315-96-8
- 7,10-Methano-7H-benzocycloundecene-8,13-dione, 1-(acetyloxy)-1,2,3,4,4a,5,6,9,10,11,12,13a-dodecahydro-6-hydroxy-4,4,13a-trimethyl-9-methylene-, (1R,4aR,6R,10R,13aS)-
- Kongensin A