KONGENSIN A
| 中文名称 | KONGENSIN A |
|---|---|
| 中文同义词 | 化合物 T5136;化合物 KONGENSIN A |
| 英文名称 | Kongensin A |
| 英文同义词 | Kongensin A;7,10-Methano-7H-benzocycloundecene-8,13-dione, 1-(acetyloxy)-1,2,3,4,4a,5,6,9,10,11,12,13a-dodecahydro-6-hydroxy-4,4,13a-trimethyl-9-methylene-, (1R,4aR,6R,10R,13aS)- |
| CAS号 | 885315-96-8 |
| 分子式 | C22H30O5 |
| 分子量 | 374.4706 |
| EINECS号 | |
| 相关类别 | 植物提取物;二萜 |
| Mol文件 | 885315-96-8.mol |
| 结构式 |  |
KONGENSIN A 性质
| 熔点 | 160-162 °C(Solv: chloroform (67-66-3)) |
|---|---|
| 沸点 | 525.7±50.0 °C(Predicted) |
| 密度 | 1.17±0.1 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.07±0.70(Predicted) |
| 颜色 | 白色至浅黄色 |
HSP90
RIP3
Apoptosis
Kongensin A (0-15 μM; 6 hours; HT29 cells) treatment induces caspase activation and apoptosis in multiple cancer cell lines in a dosage-dependent manner.
Kongensin A (0-15 μM; 24 hours; HT29 cells) treatment induces the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induces the up-regulation of HSP90A and HSP90B.
Kongensin A covalently binds to cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37. The HSP90-CDC37 complex is required for RIP3 activation, KA blocks LPS/Smac mimetics/Z-VAD and RIP3 polymerization-induced cell death, in which cell death is dependent on RIP3 but not its upstream kinase RIP1.
Apoptosis Analysis
| Cell Line: | HT29 cells |
| Concentration: | 0 μM, 2.5 μM, 5 μM, 15 μM |
| Incubation Time: | 6 hours |
| Result: | Induced caspase activation and apoptosis in a dosage-dependent manner. |
Western Blot Analysis
| Cell Line: | HT29 cells |
| Concentration: | 0 μM, 2.5 μM, 5 μM, 15 μM |
| Incubation Time: | 24 hours |
| Result: | Induced the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induced the up-regulation of HSP90A and HSP90B. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-N3417 | KONGENSIN A Kongensin A | 885315-96-8 | 1 mg | 9500元 |
| 2023/03/20 | HY-N3417 | KONGENSIN A Kongensin A | 885315-96-8 | 5 mg | 20800元 |