TCS21311; TCS-21311
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- CAS号:
- 1260181-14-3
- 英文名:
- TCS 21311
- 英文别名:
- NIBR-3049;TCS 21311;TCS21311; TCS-21311;JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem;3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-;Protein kinase C,TCS 21311,Glycogen synthase kinase 3,NIBR 3049,TCS21311,GSK-3,Glycogen synthase kinase-3,Inhibitor,JAK,inhibit,NIBR-3049,TCS-21311,Janus kinase,PKC
- 中文名:
- TCS21311; TCS-21311
- 中文别名:
- 化合物TCS 21311
- CBNumber:
- CB32546792
- 分子式:
- C27H25F3N4O4
- 分子量:
- 526.51
- MOL File:
- 1260181-14-3.mol
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TCS21311; TCS-21311化学性质
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沸点:
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793.0±60.0 °C(Predicted)
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密度:
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1.436±0.06 g/cm3(Predicted)
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储存条件:
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+2C to +8C
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溶解度:
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<52.65mg/ml in DMSO
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形态:
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Yellow solid
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酸度系数(pKa):
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7.91±0.60(Predicted)
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颜色:
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White to yellow
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TCS21311; TCS-21311性质、用途与生产工艺
TCS 21311 (NIBR3049) 是一种有效的高选择性 JAK3 抑制剂，其 IC50 为 8 nM，它的选择性是 JAK1，JAK2 和 TYK2 的100倍以上。TCS 21311 (NIBR3049) 抑制 PKCα，PKCθ 和 GSK3β，IC50 值分别为 13、68 和 3 nM。
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JAK3
8 nM (IC
50
)
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JAK2
2.55 μM (IC
50
)
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JAK1
1.017 μM (IC
50
)
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PKCα
13 nM (IC
50
)
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PKCθ
68 nM (IC
50
)
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GSK-3β
3 nM (IC
50
)
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TCS 21311 (NIBR3049) exhibits IC
50
values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively in a enzymatic Jak assay.
TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC
50
=689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity.
用途
A potent JAK3 inhibitor; selective for JAK3 over JAK1, JAK2 and TYK2. It also inhibits GSK-3β, PKCα and PKC胃.
TCS21311; TCS-21311
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-108264 | TCS21311; TCS-21311
TCS 21311 | 1260181-14-3 | 1mg | 550元 |
| 2024/04/30 | HY-108264 | TCS21311; TCS-21311
TCS 21311 | 1260181-14-3 | 5mg | 1800元 |
1260181-14-3, TCS21311; TCS-21311 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- Heterocycles
- Aromatics
- C27H25F3N4O4
- 化合物TCS 21311
- 1260181-14-3
- Protein kinase C,TCS 21311,Glycogen synthase kinase 3,NIBR 3049,TCS21311,GSK-3,Glycogen synthase kinase-3,Inhibitor,JAK,inhibit,NIBR-3049,TCS-21311,Janus kinase,PKC
- 1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-
- 3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione
- JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem
- TCS21311; TCS-21311
- NIBR-3049
- TCS 21311
- 3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione