TCS21311; TCS-21311
| 中文名称 | TCS21311; TCS-21311 |
|---|---|
| 中文同义词 | 化合物TCS 21311 |
| 英文名称 | TCS 21311 |
| 英文同义词 | 3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;TCS 21311;NIBR-3049;TCS21311; TCS-21311;JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem;3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-;Protein kinase C,TCS 21311,Glycogen synthase kinase 3,NIBR 3049,TCS21311,GSK-3,Glycogen synthase kinase-3,Inhibitor,JAK,inhibit,NIBR-3049,TCS-21311,Janus kinase,PKC |
| CAS号 | 1260181-14-3 |
| 分子式 | C27H25F3N4O4 |
| 分子量 | 526.51 |
| EINECS号 | |
| 相关类别 | Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 1260181-14-3.mol |
| 结构式 |  |
TCS21311; TCS-21311 性质
| 沸点 | 793.0±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.436±0.06 g/cm3(Predicted) |
| 储存条件 | +2C to +8C |
| 溶解度 | <52.65mg/ml，溶于 DMSO |
| 形态 | 黄色固体 |
| 酸度系数(pKa) | 7.91±0.60(Predicted) |
| 颜色 | 白色至黄色 |
|
JAK3 8 nM (IC 50 ) |
JAK2 2.55 μM (IC 50 ) |
JAK1 1.017 μM (IC 50 ) |
PKCα 13 nM (IC 50 ) |
PKCθ 68 nM (IC 50 ) |
GSK-3β 3 nM (IC 50 ) |
TCS 21311 (NIBR3049) exhibits IC 50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively in a enzymatic Jak assay. TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC 50 =689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-108264 | TCS21311; TCS-21311 TCS 21311 | 1260181-14-3 | 1mg | 550元 |
| 2024/08/19 | HY-108264 | TCS21311; TCS-21311 TCS 21311 | 1260181-14-3 | 5mg | 1800元 |