| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:TCS-21311
CAS:1260181-14-3
Package:100Mg,10Mg
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| | TCS 21311 Basic information |
| Product Name: | TCS 21311 | | Synonyms: | 3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;TCS 21311;NIBR-3049;TCS21311; TCS-21311;JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem;3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-;Protein kinase C,TCS 21311,Glycogen synthase kinase 3,NIBR 3049,TCS21311,GSK-3,Glycogen synthase kinase-3,Inhibitor,JAK,inhibit,NIBR-3049,TCS-21311,Janus kinase,PKC | | CAS: | 1260181-14-3 | | MF: | C27H25F3N4O4 | | MW: | 526.51 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 1260181-14-3.mol |  |
| | TCS 21311 Chemical Properties |
| Boiling point | 793.0±60.0 °C(Predicted) | | density | 1.436±0.06 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | <52.65mg/ml in DMSO | | form | Yellow solid | | pka | 7.91±0.60(Predicted) | | color | White to yellow |
| | TCS 21311 Usage And Synthesis |
| Uses | A potent JAK3 inhibitor; selective for JAK3 over JAK1, JAK2 and TYK2. It also inhibits GSK-3β, PKCα and PKCθ. | | Biological Activity | tcs 21311 is a potent and selective jak3 inhibitor with the ic50 values of 8 nm. tcs 21311 shows high selectivity for jak3 over jak1, jak2 and tyk2. the ic50 values are 1017, 2550 and 8055 nm respectively. tcs 21311 exihibits inhibitory effect on gsk-3β, pkcα and pkcθ with the ic50 values of 3, 13 and 68 nm, respectively [1].janus kinases (jak) belong to a small family of cytoplasmic protein tyrosine kinases including jak1, jak2, tyk2, and jak3, which play important roles in initiating the cytokine-triggered signaling events by activators of transcription (stat) proteins via tyrosine phosphorylation [2]. due to its association with relevant cytokine signaling pathways, jak3 serves as an important target for therapeutic intervention in the treatment of inflammatory diseases, autoimmune disorders and organ transplant rejection [2]. | | storage | Desiccate at RT | | references | [1] thoma g, nuninger f, falchetto r, et al. identification of a potent janus kinase 3 inhibitor with high selectivity within the janus kinase family[j]. journal of medicinal chemistry, 2010, 54(1): 284-288.
[2] clark m p, george k m, bookland r g, et al. development of new pyrrolopyrimidine-based inhibitors of janus kinase 3 (jak3)[j]. bioorganic & medicinal chemistry letters, 2007, 17(5): 1250-1253. |
| | TCS 21311 Preparation Products And Raw materials |
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