化合物 T16709
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- CAS号:
- 93076-89-2
- 英文名:
- DIACYLGLYCEROL KINASE INHIBITOR I
- 英文别名:
- DKI;DAGK;DGKE;DGKI;DAGK4;DAGK7;DGK-θ;R59022;DKGI-I;DAG KINASE
- 中文名:
- 化合物 T16709
- 中文别名:
- 甘油二酯激酶;二乙酰基甘油激酶;二酰基甘油激酶抑制剂;化合物 T16709;二酰基甘油激酶5/DGK-Ε抗体;R 59-022,二酰基甘油激酶抑制剂
- CBNumber:
- CB3335279
- 分子式:
- C27H26FN3OS
- 分子量:
- 459.58
- MOL File:
- 93076-89-2.mol
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化合物 T16709化学性质
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沸点:
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619.8±65.0 °C(Predicted)
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密度:
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1.26±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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0.1 M HCl: slightly soluble
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形态:
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solid
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酸度系数(pKa):
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7.76±0.20(Predicted)
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颜色:
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pale yellow
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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化合物 T16709性质、用途与生产工艺
R 59-022 (DKGI-I) 是一种二酰甘油激酶 (diacylglycerol kinase) 抑制剂 (IC50=2.8 μM)。R 59-022 是一种 5-HTR 拮抗剂,激活蛋白激酶 C (PKC)。R 59-022 增强凝血酶诱导血小板产生二酰甘油和抑制中性粒细胞产生磷脂酸。
PKC
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serotonin
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diacylglycerol kinase
2.8 μM (IC
50
)
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In the intact platelet, R 59-022 is able to interrupts thrombin-induced inositol lipid cycling at the level of diacylglycerol and leads to an elevation of protein kinase C activity.
R 59-022 (10 μM) potentiates aggregation, but not shape change induced by sub-maximal concentrations of thrombin. R59022 (10 μM) had no significant effect on the dose-response curve for the mobilization of intracellular Ca
2+
by thrombin in either the presence or the absence of extracellular Ca
2+
.
R 59-022, an inhibitor of filovirus entry, prevents the macropinocytic uptake of filoviral particles, inhibits entry mediated by multiple filovirus GPs, and blocks replicative EBOV growth. R 59-022 blocks entry of EBOV pseudotypes in a concentration-dependent manner (IC
50
: ~5 µM). R 59-022 dose-dependent decreases in entry by the VLPs harboring the EBOV GP (IC
50
: ~2 µM). R 59-022 (2-12 μM; 1 hour) can inhibit EBOV GP-mediated entry in multiple cell types. R 59-022 (5 µM; 30 minutes) blocks macropinocytosis in vero cells.
化合物 T16709
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-107613 | R 59-022 | | 1 mg | 1127元 |
2024/04/30 | HY-107613 | 化合物 T16709 R 59-022 | 93076-89-2 | 5mg | 3100元 |
93076-89-2, 化合物 T16709 相关搜索:
异腈基正丁烷 乙酰丙酮银 异氰基乙酸乙酯 苯硒酚 1,1,3,3-四甲基丁基异氰 对甲基苯磺酰甲基异腈 2,2,6,6-四甲基-3,5-庚烷二酸镝 双水杨酰胺乙基钴 乙酰丙酮钴水合物 乙二胺氯化铂 利坦丝林 异氰酸叔丁酯 乙酰丙酮酸铜 异腈基乙酸甲酯 三(2,2,6,6-四甲基-3,5-庚二酸)铕 三乙酰丙酮铝 乙酰丙酮铬盐 苄异腈
- Lipid signaling
- 酶
- BioChemical
- Biochemicals and Reagents
- Application Index
- Cell Signaling Enzymes
- Cell Signaling and Neuroscience
- Cell Biology
- Kinase/Phosphatase Biology
- Serine/Threonine Kinase Inhibitors
- Signal Transduction
- Enzymes, Inhibitors, and Substrates
- Diacylglycerol kinase (DAGK)
- 二酰基甘油激酶抑制剂
- R 59-022,二酰基甘油激酶抑制剂
- 甘油二酯激酶
- 二乙酰基甘油激酶
- 化合物 T16709
- 二酰基甘油激酶5/DGK-Ε抗体
- 93076-89-2
- R 59022,R 59 022
- DKGI-I
- Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem
- 6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
- 6-[2-[4-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE
- 6-[2-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL)ETHYL]-7-METHYL-5H-THIAZOLO-[3,2-A]-PYRIMIDIN-5-ONE
- 6-[2-[4-[(P-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO(3,2-A)PYRIMIDINE-5-ONE
- Anti-DGKD, N-Terminal antibody produced in rabbit
- Diglyceride kinase κ
- DGKI
- Anti-DGKI, C-Terminal antibody produced in rabbit
- DGK-θ
- DAGK7
- DAGK4
- Anti-DGKQ, C-Terminal antibody produced in rabbit
- DGKE
- 6-[2-[4-[(4-Fluorophenyl)phenylMethylene]-1-piperidin-yl]ethyl]-7-Methyl-5H-thiazolo-[3,2-a]-pyriMidin-5-one, R59022
- 6-(2-(4-((4-Fluorophenyl)phenylmethylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo(3,2-A)pyrimidine-5-one
- 5H-Thiazolo(3,2-A)pyrimidin-5-one, 6-(2-(4-((4-fluorophenyl)phenylmethylene)-1-piperidinyl)ethyl)-7-methyl-
- sn-1,2-Diacylglycerol kinase, DAGK
- Diacylglycerol Kinase from Escherichia coli
- R59022, 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one
- DIACYLGLYCEROL KINASE SOLUTION
- 6-[2-[4-[(4-fluorophenyl)phenylmethylene]-1-piperidin-yl]ethyl]-7-methyl-5h-thiazolo-[3,2-a]-pyrimidin-5-one
- DIACYLGLYCEROL KINASE FROM E. COLI
- R59022
- SN-1,2-DIACYLGLYCEROL KINASE, RECOMBINANT, E COLI
- SN-1,2-DIACYLGLYCEROL KINASE
- DKI
- EC: 2.7.1.107
- EC 2.7.1.107
- DAG KINASE
- DAGK
- DIACYLGLYCEROL KINASE INHIBITOR I (R59 022)
- DIACYLGLYCEROL KINASE INHIBITOR I
- DIACYLGLYCEROL KINASE