化合物 T16709
中文名称 | 化合物 T16709 |
---|---|
中文同义词 | 二酰基甘油激酶5/DGK-Ε抗体;化合物 T16709;二乙酰基甘油激酶;甘油二酯激酶;R 59-022,二酰基甘油激酶抑制剂;二酰基甘油激酶抑制剂 |
英文名称 | DIACYLGLYCEROL KINASE INHIBITOR I |
英文同义词 | DIACYLGLYCEROL KINASE;DIACYLGLYCEROL KINASE INHIBITOR I;DIACYLGLYCEROL KINASE INHIBITOR I (R59 022);DAGK;DAG KINASE;EC 2.7.1.107;EC: 2.7.1.107;DKI |
CAS号 | 93076-89-2 |
分子式 | C27H26FN3OS |
分子量 | 459.58 |
EINECS号 | |
相关类别 | Lipid signaling |
Mol文件 | 93076-89-2.mol |
结构式 | ![]() |
化合物 T16709 性质
沸点 | 619.8±65.0 °C(Predicted) |
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密度 | 1.26±0.1 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 0.1 M HCl:微溶 |
形态 | 固体 |
酸度系数(pKa) | 7.76±0.20(Predicted) |
颜色 | 淡黄色低 |
稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
PKC
|
serotonin
|
diacylglycerol kinase 2.8 μM (IC 50 ) |
In the intact platelet, R 59-022 is able to interrupts thrombin-induced inositol lipid cycling at the level of diacylglycerol and leads to an elevation of protein kinase C activity.
R 59-022 (10 μM) potentiates aggregation, but not shape change induced by sub-maximal concentrations of thrombin. R59022 (10 μM) had no significant effect on the dose-response curve for the mobilization of intracellular Ca
2+
by thrombin in either the presence or the absence of extracellular Ca
2+
.
R 59-022, an inhibitor of filovirus entry, prevents the macropinocytic uptake of filoviral particles, inhibits entry mediated by multiple filovirus GPs, and blocks replicative EBOV growth. R 59-022 blocks entry of EBOV pseudotypes in a concentration-dependent manner (IC
50
: ~5 µM). R 59-022 dose-dependent decreases in entry by the VLPs harboring the EBOV GP (IC
50
: ~2 µM). R 59-022 (2-12 μM; 1 hour) can inhibit EBOV GP-mediated entry in multiple cell types. R 59-022 (5 µM; 30 minutes) blocks macropinocytosis in vero cells.
安全信息
安全说明 | 23-24/25 |
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WGK Germany | 3 |
提供商 | 语言 |
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英文
|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-107613 | R 59-022 | 1 mg | 1127元 | |
2024/04/30 | HY-107613 | 化合物 T16709 R 59-022 | 93076-89-2 | 5mg | 3100元 |