[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone

生物活性靶点体外研究 [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone 试剂级价格

CAS号:: 7733-96-2

英文名:: [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone

英文别名:: HC-056456;HC-056456,inhibit,HC056456,Inhibitor;3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide;HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide);HC-056456 (Synonyms: 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide);Methanone, 1,1'-(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[1-(2-thienyl)-;[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone

中文名:: [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone

中文别名:: 化合物HC-056456

CBNumber:: CB34581986

分子式:: C12H6N2O4S2

分子量:: 306.32

MOL File:: 7733-96-2.mol

化学性质安全信息用途价格供应商 13

[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone化学性质

熔点:: 113-114 °C(Solv: heptane (142-82-5))

沸点:: 572.1±60.0 °C(Predicted)

密度:: 1.67±0.1 g/cm3(Predicted)

储存条件:: Store at -20°C

溶解度:: DMSO:150.0(Max Conc. mg/mL);489.7(Max Conc. mM)

形态:: Solid

酸度系数(pKa):: -4.77±0.10(Predicted)

颜色:: White to off-white

安全信息

海关编码:	2934999090

[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone性质、用途与生产工艺

生物活性

HC-056456 是一种有效但不完全选择性的 CatSper 通道阻断剂。HC-056456 减慢 [Na+]i 上升，IC50 为 3 µM。

HC-056456 similarly slows the rise of [Ca ²⁺ ] _i that is evoked by alkaline depolarization and reported by fura-2. HC-056456 also selectively and reversibly decreased CatSper currents recorded from patch-clamped sperm. HC-056456 produces a pharmacological phenocopy of the CatSper-null sperm. Acute application of HC-056456 causes rapid loss of flagellar waveform asymmetry from hyperactivated sperm, indicating that continued entry of Ca ²⁺ through CatSper channels is required to maintain hyperactivation. HC-056456 selectively and reversibly blocks CatSper currents. The specificity and reversibility of the blockade of CatSper-dependent currents by HC-056456 is examined by using patch clamp recordings. The observed current is blocked slightly more than 50% by 20 µM HC-056456 (estimated IC ₅₀ near 15 µM). In concept, it remains possible that CatSper channel heterogeneity explains residual HC-056456-resistant current. The action of HC-056456 on KSper channels, the other major cation channel observed in patch-clamped sperm, is also examined. Subsequent application of 50 µM HC-056456 results in partial blockade of this current. For HC-056456 action on KSper an IC ₅₀ near 40 µM is estimated.

[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone 上下游产品信息

上游原料

下游产品

[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/04/30	HY-112729	HC-056456		1 mg	304元
2024/04/30	HY-112729	[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone HC-056456	7733-96-2	5mg	900元

[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone 生产厂家

全球有 13家供应商 [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
上海源溪生物科技有限公司	021-58447131 13564518121	sales@dcchemicals.com	中国	9412	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
上海弘渠生物医药科技有限公司	88888888888	hongquchem@qq.com	中国	5132	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
上海杰瑞兴生物医药科技有限公司	17721492509	643638326@qq.com	中国	5347	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	美国	19973	58

7733-96-2, [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone 相关搜索:

化合物HC-056456
7733-96-2
Methanone, 1,1'-(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[1-(2-thienyl)-
HC-056456,inhibit,HC056456,Inhibitor
3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide
HC-056456 (Synonyms: 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide)
HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide)
[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone
HC-056456