[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone
中文名称 | [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone |
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中文同义词 | 化合物HC-056456 |
英文名称 | [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone |
英文同义词 | HC-056456;[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone;HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide);HC-056456 (Synonyms: 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide);3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide;HC-056456,inhibit,HC056456,Inhibitor;Methanone, 1,1'-(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[1-(2-thienyl)- |
CAS号 | 7733-96-2 |
分子式 | C12H6N2O4S2 |
分子量 | 306.32 |
EINECS号 | |
相关类别 | |
Mol文件 | 7733-96-2.mol |
结构式 | ![]() |
[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone 性质
熔点 | 113-114 °C(Solv: heptane (142-82-5)) |
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沸点 | 572.1±60.0 °C(Predicted) |
密度 | 1.67±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:150.0(最大浓度 mg/mL);489.7(最大浓度 mM) |
形态 | 固体 |
酸度系数(pKa) | -4.77±0.10(Predicted) |
颜色 | 白色至米白色 |
CatSper
HC-056456 similarly slows the rise of [Ca 2+ ] i that is evoked by alkaline depolarization and reported by fura-2. HC-056456 also selectively and reversibly decreased CatSper currents recorded from patch-clamped sperm. HC-056456 produces a pharmacological phenocopy of the CatSper-null sperm. Acute application of HC-056456 causes rapid loss of flagellar waveform asymmetry from hyperactivated sperm, indicating that continued entry of Ca 2+ through CatSper channels is required to maintain hyperactivation. HC-056456 selectively and reversibly blocks CatSper currents. The specificity and reversibility of the blockade of CatSper-dependent currents by HC-056456 is examined by using patch clamp recordings. The observed current is blocked slightly more than 50% by 20 µM HC-056456 (estimated IC 50 near 15 µM). In concept, it remains possible that CatSper channel heterogeneity explains residual HC-056456-resistant current. The action of HC-056456 on KSper channels, the other major cation channel observed in patch-clamped sperm, is also examined. Subsequent application of 50 µM HC-056456 results in partial blockade of this current. For HC-056456 action on KSper an IC 50 near 40 µM is estimated.
安全信息
海关编码 | 2934999090 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-112729 | HC-056456 | 1 mg | 304元 | |
2024/08/19 | HY-112729 | [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone HC-056456 | 7733-96-2 | 5mg | 900元 |