BW 245C
|
|
- CAS号:
- 72814-32-5
- 英文名:
- BW 245C
- 英文别名:
- BW 245C;3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-(R*,S*)-(±)-4-imidazolineheptanioc acid;3-(3-CYCLOHEXYL-3-HYDROXYPROPYL)-2,5-DIOXO-(R*,S*)-(+/-)-4-IMIDAZOLINEHEPTANOIC ACID;(4S)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID;4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (R*,S*)-( -)-;4-Imidazolidineheptanoic acid, 3-[(3S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo-, (4R)-rel-;4-Imidazolidineheptanoic acid, 3-((3R)-3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (4S)-rel-
- 中文名:
- BW 245C
- 中文别名:
- 化合物 T14842
- CBNumber:
- CB3463374
- 分子式:
- C19H32N2O5
- 分子量:
- 368.47
- MOL File:
- 72814-32-5.mol
|
|
|
BW 245C化学性质
-
密度:
-
1.167±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
−20°C
-
|
-
溶解度:
-
DMSO: 30 mg/mL, soluble
-
|
-
形态:
-
solid
-
|
-
酸度系数(pKa):
-
4.77±0.10(Predicted)
-
|
-
颜色:
-
off-white
-
|
BW 245C性质、用途与生产工艺
BW 245C 是一种有效的前列腺素类DP受体prostanoid DP-receptor (DP1)激动剂,常用于中风等疾病的研究。
BW245C (0.01-1 μM) suppresses TGF-β-induced collagen secretion in a dose-dependent manner in Th2 cells. BW245C (0.01-1 μM) also increases intracellular cAMP in lung fibroblasts. BW245C (0.1-3 μmol/L) dose-dependently increases transendothelial electrical resistance and decreases the FITC-dextran permeability of human umbilical vein endothelial cells. BW245C (0.3 μmol/L) increases the intracellular cAMP level and subsequent protein kinase A (PKA) activity.
BW245C (0.02, 0.2, and 2.0 mg/kg) in WT mice results in a significant increase in CBF, but this effect of this treatment is absent in DP1
−/−
mice. BW245C attenuates functional deficits after stroke. BW245C significantly reverses these conditions that neurologic deficit is significantly augmented, whereas locomotor activity is significantly reduced after stroke in WT mice. BW245C (0.2 mg/kg) injection 1 h after stroke results in a significant decrease in brain infarction in WT mice, whereas the effect of this treatment is not observed in DP1
−/−
mice. BW245C improves CBF during and after stroke. BW245C results in significantly prolonged bleeding compared with the vehicle-treated group. BW 245C (100 nM) does not significantly increase MBP-positive eosinophils in esophageal epithelium in OVA-sensitized guinea pigs.
BW 245C
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-101987 | BW 245C BW 245C | 72814-32-5 | 1mg | 1400元 |
2024/08/19 | HY-101987 | BW 245C BW 245C | 72814-32-5 | 10 mM * 1 mLin DMSO | 2432元 |
72814-32-5, BW 245C 相关搜索:
- 化合物 T14842
- 72814-32-5
- 4-Imidazolidineheptanoic acid, 3-[(3S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo-, (4R)-rel-
- 3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-(R*,S*)-(±)-4-imidazolineheptanioc acid
- 4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (R*,S*)-( -)-
- 4-Imidazolidineheptanoic acid, 3-((3R)-3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (4S)-rel-
- 3-(3-CYCLOHEXYL-3-HYDROXYPROPYL)-2,5-DIOXO-(R*,S*)-(+/-)-4-IMIDAZOLINEHEPTANOIC ACID
- (4S)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID
- BW 245C