BW 245C
- CAS No.
- 72814-32-5
- Chemical Name:
- BW 245C
- Synonyms
- BW 245C;3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-(R*,S*)-(±)-4-imidazolineheptanioc acid;3-(3-CYCLOHEXYL-3-HYDROXYPROPYL)-2,5-DIOXO-(R*,S*)-(+/-)-4-IMIDAZOLINEHEPTANOIC ACID;(4S)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID;4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (R*,S*)-( -)-;4-Imidazolidineheptanoic acid, 3-[(3S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo-, (4R)-rel-;4-Imidazolidineheptanoic acid, 3-((3R)-3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (4S)-rel-
- CBNumber:
- CB3463374
- Molecular Formula:
- C19H32N2O5
- Molecular Weight:
- 368.47
- MDL Number:
- MFCD00216042
- MOL File:
- 72814-32-5.mol
- MSDS File:
- SDS
| Density | 1.167±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | −20°C |
| solubility | DMSO: 30 mg/mL, soluble |
| form | solid |
| pka | 4.77±0.10(Predicted) |
| color | off-white |
| EWG's Food Scores | 1 |
| FDA UNII | 5B26TJM1L8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
BW 245C price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 12050 | BW 245C ≥98% | 72814-32-5 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 12050 | BW 245C ≥98% | 72814-32-5 | 5mg | $302 | 2024-03-01 | Buy |
| Cayman Chemical | 12050 | BW 245C ≥98% | 72814-32-5 | 10mg | $535 | 2024-03-01 | Buy |
| TRC | B820013 | BW245C | 72814-32-5 | 5mg | $220 | 2021-12-16 | Buy |
| ChemScene | CS-6941 | BW245C 99.14% | 72814-32-5 | 1mg | $250 | 2021-12-16 | Buy |
BW 245C Chemical Properties,Uses,Production
Uses
BW 245C is a DP agonist, affecting the signaling pathway on primary cultured rat hippocampal neuron injuries.
Definition
ChEBI: (3R,4S)-BW 245C is a 7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid that is the (3R,4S)-enantiomer of BW 245C. It is an enantiomer of a (3S,4R)-BW 245C.
Biological Activity
bw 245c is a kind of prostaglandin analogue with stable chemical properties which functions as a potent inhibitor of platelet aggregation. bw 245c could selectively active the dp1 receptor, and inhibit [3h]-pgd2 binding to isolated human platelet membranes, with the ki value of 0.9 nm [1].
in vitro
bw 245c could inhibit the aggregation of human and rat platelets induced by adp in a dose dependent manner, with the ic50 values of 8.7 nm and 9.9 nm, respectively [1]. besides, in hek293 cells stably expressing the hdp receptor, bw 245c could significantly increase camp production, with the ec50 value of 0.7 nm [2].
in vivo
in spontaneously hypertensive rats, intravenous bolus injection with bw 245c at the dose of 250 μg/kg could reduce the systolic and diastolic blood pressure by 23% and 34%, respectively [1].
target
dp1 receptor
IC 50
2.5 nm
References
[1] town h c, casalsstenzel j, schillinger e, et al. pharmacological and cardiovascular properties of a hydantoin derivative, bw 245 c, with high affinity and selectivity for pgd2 receptors[j]. prostaglandins, 1983, 25(1): 13-28.
[2] boie y, sawyer n, slipetz d, et al. molecular cloning and characterization of the human prostanoid dp receptor[j]. journal of biological chemistry, 1995, 270(32): 18910-18916.
[3] orchard m a, ritter j m, shepherd g l, et al. cardiovascular and platelet effects in man of bw 245c, a stable mimic of epoprostenol (pgi2)[j]. british journal of clinical pharmacology, 1983, 15(5): 509-511.
BW 245C Preparation Products And Raw materials
Raw materials
Preparation Products
BW 245C Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2210 | 55 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2539 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |