CS-2850
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- CAS号:
- 1041852-85-0
- 英文名:
- AZD7507
- 英文别名:
- AZD7507;CS-2850;AZD7507; AZD-7507; AZD 7507;1041852-85-0;4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide;3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-;AZD7507,AZD 7507,Inhibitor,AZD-7507,CSF-1R,CSF1R,CSF-1 receptor,c-Fms,inhibit,colony stimulating factor 1 receptor
- 中文名:
- CS-2850
- 中文别名:
- 化合物CS-2850;4-((2-氟-4-甲基苯基)氨基)-6-(4-(2-羟乙基)哌嗪-1-基)-7-甲氧基噌啉-3-甲酰胺
- CBNumber:
- CB34804162
- 分子式:
- C23H27FN6O3
- 分子量:
- 454.5
- MOL File:
- 1041852-85-0.mol
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CS-2850化学性质
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沸点:
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680.7±65.0 °C(Predicted)
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密度:
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1.346±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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14.47±0.30(Predicted)
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颜色:
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Light yellow to yellow
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CS-2850性质、用途与生产工艺
AZD7507 为一种有效的、可口服的 CSF-1R 抑制剂,具有抗肿瘤活性。
AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC
50
, 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC
50
s of >30 and 26 μM.
AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC
50
is >20 μM. AZD7507 significantly decreases the number of CD68
+
macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells.
CS-2850
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-117244 | AZD7507 | | 1 mg | 863元 |
2024/08/19 | HY-117244 | CS-2850 AZD7507 | 1041852-85-0 | 5mg | 1900元 |
1041852-85-0, CS-2850 相关搜索:
- C23H27FN6O3
- 4-((2-氟-4-甲基苯基)氨基)-6-(4-(2-羟乙基)哌嗪-1-基)-7-甲氧基噌啉-3-甲酰胺
- 化合物CS-2850
- 1041852-85-0
- AZD7507,AZD 7507,Inhibitor,AZD-7507,CSF-1R,CSF1R,CSF-1 receptor,c-Fms,inhibit,colony stimulating factor 1 receptor
- 3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-
- 4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide
- CS-2850
- AZD7507; AZD-7507; AZD 7507;1041852-85-0
- AZD7507