CS-2850
| 中文名称 | CS-2850 |
|---|---|
| 中文同义词 | 化合物CS-2850;4-((2-氟-4-甲基苯基)氨基)-6-(4-(2-羟乙基)哌嗪-1-基)-7-甲氧基噌啉-3-甲酰胺 |
| 英文名称 | AZD7507 |
| 英文同义词 | AZD7507;AZD7507; AZD-7507; AZD 7507;1041852-85-0;CS-2850;4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide;3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-;AZD7507,AZD 7507,Inhibitor,AZD-7507,CSF-1R,CSF1R,CSF-1 receptor,c-Fms,inhibit,colony stimulating factor 1 receptor |
| CAS号 | 1041852-85-0 |
| 分子式 | C23H27FN6O3 |
| 分子量 | 454.5 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1041852-85-0.mol |
| 结构式 |  |
CS-2850 性质
| 沸点 | 680.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.346±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.47±0.30(Predicted) |
| 颜色 | 浅黄至黄色 |
AZD7507 为一种有效的、可口服的 CSF-1R 抑制剂，具有抗肿瘤活性。
CSF-1R
AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC 50 , 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC 50 s of >30 and 26 μM.
AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC 50 is >20 μM. AZD7507 significantly decreases the number of CD68 + macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-117244 | AZD7507 | 1 mg | 863元 | |
| 2024/04/30 | HY-117244 | CS-2850 AZD7507 | 1041852-85-0 | 5mg | 1900元 |