JC-171
(JC171)
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- CAS号:
- 2112809-98-8
- 英文名:
- JC-171
(JC171)
- 英文别名:
- JC-171
(JC171);Benzamide, 5-chloro-N-[2-[4-[(hydroxyamino)sulfonyl]phenyl]ethyl]-2-methoxy-
- 中文名:
- JC-171
(JC171)
- 中文别名:
- CBNumber:
- CB34844922
- 分子式:
- C16H17ClN2O5S
- 分子量:
- 384.83
- MOL File:
- 2112809-98-8.mol
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JC-171
(JC171)化学性质
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密度:
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1.401±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (649.64 mM)
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形态:
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Solid
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酸度系数(pKa):
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6.43±0.69(Predicted)
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颜色:
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White to off-white
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JC-171
(JC171)性质、用途与生产工艺
JC-171 是选择性的 NLRP3 炎症小体抑制剂，抑制 LPS/ATP 诱导的巨噬细胞释放 IL-1β 的 IC50 值为 8.45 μM。
JC-171 (0-100 μM) blocks NLRP3 inflammasome activation and IL-1β production in primary macrophages dose dependently.
Cell Viability Assay
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Cell Line:
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J774A.1 murine macrophage cells
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Concentration:
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0-100 μM.
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Incubation Time:
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0.5 h (before LPS (1 μg/mL) treatment for 4.5 h).
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Result:
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Inhibited the release of IL-1β in J774A.1 cells upon stimulation with LPS/ATP.
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JC-171 treatment delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE) in mouse.
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Animal Model:
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Mice immunized subcutaneously with 200 μg Myelin oligodendrocyte glycoprotein (MOG)
35–55
peptide emulsified in Complete Freund’s Adjuvant (CFA) on day 0 followed by injection of 200 ng of pertussis toxin.
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Dosage:
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100 mg/kg, 10 mg/kg.
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Administration:
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IP days 0, 1 and 2; and every other days thereafter (100 mg/kg).
Initiated when the clinical scores of individual mice have reached 1 (flaccid tail), and given every other day (10 mg/kg).
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Result:
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Efficiently suppressed EAE progression compared with vehicle treatment.
Resulted in a substantial decrease in the frequency of MOG
35–55
-specific Th17 cells in the spleens and spinal cords of EAE mice.
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JC-171
(JC171)
上下游产品信息
上游原料
下游产品
2112809-98-8, JC-171
(JC171) 相关搜索:
- 2112809-98-8
- Benzamide, 5-chloro-N-[2-[4-[(hydroxyamino)sulfonyl]phenyl]ethyl]-2-methoxy-
- JC-171
(JC171)