DIDESMETHYLROCAGLAMIDE

生物活性靶点体外研究 DIDESMETHYLROCAGLAMIDE 试剂级价格

CAS号:: 177262-30-5

英文名:: 1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, (1R,2R,3S,3aR,8bS)-

英文别名:: Didesmethylrocaglamide;(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide;1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, (1R,2R,3S,3aR,8bS)-

中文名:: DIDESMETHYLROCAGLAMIDE

中文别名:

CBNumber:: CB38108051

分子式:: C27H27NO7

分子量:: 477.51

MOL File:: 177262-30-5.mol

化学性质安全信息用途价格供应商 12

DIDESMETHYLROCAGLAMIDE化学性质

沸点:: 691.4±55.0 °C(Predicted)

密度:: 1.379±0.06 g/cm3(Predicted)

储存条件:: Store at -20°C

溶解度:: DMSO: 100 mg/mL (209.42 mM)

形态:: Solid

酸度系数(pKa):: 11.70±0.70(Predicted)

颜色:: White to off-white

安全信息

DIDESMETHYLROCAGLAMIDE性质、用途与生产工艺

生物活性

Didesmethylrocaglamide 是一种 Rocaglamide 的衍生物，也是一种有效的真核起始因子 4A (eIF4A) 抑制剂。Didesmethylrocaglamide 具有有效的生长抑制活性，IC50 为 5 nM。Didesmethylrocaglamide 抑制多种促进生长的信号通路，并诱导肿瘤细胞凋亡 (apoptosis)。抗肿瘤活性。

Didesmethylrocaglamide (5 nM, and 10 nM; 72 hours; MPNST cells) treatment arrests MPNST cells at G2-M, increases the sub-G1 population, induces cleavage of caspases and PARP, and elevates the levels of the DNA-damage response marker γH2A.X, while decreasing the expression of AKT and ERK1/2.
Didesmethylrocaglamide inhibits MPNST cell proliferation by inducing cell cycle arrest at G2/M and subsequently, cell death. Didesmethylrocaglamide-treated 697-R cells exhibits IC ₅₀ values is very similar to those of parental 697 cells (4 vs 3nM of IC ₅₀ , respectively).
Didesmethylrocaglamide induces apoptosis in both neurofibromatosis type 1 (NF1)-expressing and NF1-deficient MPNST cells, possibly subsequent to the activation of the DNA damage response. Didesmethylrocaglamide-treated sarcoma cells show decreased levels of multiple oncogenic kinases, including insulin-like growth factor-1 receptor.

Western Blot Analysis

Cell Line:	Malignant peripheral nerve sheath tumors (MPNST) cells
Concentration:	5 nM, and 10 nM
Incubation Time:	72 hours
Result:	Induced cleavage of caspases and PARP, and elevated the levels of the DNA-damage response marker γH2A.X.

DIDESMETHYLROCAGLAMIDE 上下游产品信息

上游原料

下游产品

DIDESMETHYLROCAGLAMIDE 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/04/30	HY-19356A	Didesmethylrocaglamide		1 mg	2600元
2024/04/30	HY-19356A	DIDESMETHYLROCAGLAMIDE Didesmethylrocaglamide	177262-30-5	5mg	5800元

DIDESMETHYLROCAGLAMIDE 生产厂家

全球有 12家供应商 DIDESMETHYLROCAGLAMIDE国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
北京普西唐生物科技有限公司	010-60605840 18892239720	psaitong@jm-bio.com	中国	12308	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	美国	6393	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	中国	19994	58
上海源溪生物科技有限公司	021-58447131 13564518121	sales@dcchemicals.com	中国	9412	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
InvivoChem中国	13549236410	sales@invivochem.cn	中国	6749	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
上海一研生物科技有限公司	021-69985186 13611928337	3427709316@qq.com	中国	7984	58
銳迪國際科技有限公司	18024082417	market@ubiochem.com	中国	9155	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	美国	52927	58

177262-30-5, DIDESMETHYLROCAGLAMIDE 相关搜索:

抑制剂
177262-30-5
(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide
Didesmethylrocaglamide
1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, (1R,2R,3S,3aR,8bS)-