DIDESMETHYLROCAGLAMIDE
| 中文名称 | DIDESMETHYLROCAGLAMIDE |
|---|---|
| 中文同义词 | |
| 英文名称 | 1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, (1R,2R,3S,3aR,8bS)- |
| 英文同义词 | 1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, (1R,2R,3S,3aR,8bS)-;Didesmethylrocaglamide;(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide |
| CAS号 | 177262-30-5 |
| 分子式 | C27H27NO7 |
| 分子量 | 477.51 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 177262-30-5.mol |
| 结构式 |  |
DIDESMETHYLROCAGLAMIDE 性质
| 沸点 | 691.4±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.379±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：100 mg/mL（209.42 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.70±0.70(Predicted) |
| 颜色 | 白色至米白色 |
Eukaryotic initiation factor 4A (eIF4A)
Didesmethylrocaglamide (5 nM, and 10 nM; 72 hours; MPNST cells) treatment arrests MPNST cells at G2-M, increases the sub-G1 population, induces cleavage of caspases and PARP, and elevates the levels of the DNA-damage response marker γH2A.X, while decreasing the expression of AKT and ERK1/2.
Didesmethylrocaglamide inhibits MPNST cell proliferation by inducing cell cycle arrest at G2/M and subsequently, cell death. Didesmethylrocaglamide-treated 697-R cells exhibits IC
50
values is very similar to those of parental 697 cells (4 vs 3nM of IC
50
, respectively).
Didesmethylrocaglamide induces apoptosis in both neurofibromatosis type 1 (NF1)-expressing and NF1-deficient MPNST cells, possibly subsequent to the activation of the DNA damage response. Didesmethylrocaglamide-treated sarcoma cells show decreased levels of multiple oncogenic kinases, including insulin-like growth factor-1 receptor.
Western Blot Analysis
| Cell Line: | Malignant peripheral nerve sheath tumors (MPNST) cells |
| Concentration: | 5 nM, and 10 nM |
| Incubation Time: | 72 hours |
| Result: | Induced cleavage of caspases and PARP, and elevated the levels of the DNA-damage response marker γH2A.X. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-19356A | Didesmethylrocaglamide | 1 mg | 2600元 | |
| 2024/04/30 | HY-19356A | DIDESMETHYLROCAGLAMIDE Didesmethylrocaglamide | 177262-30-5 | 5mg | 5800元 |