BAY-X 1005
|
|
- CAS号:
- 128253-31-6
- 英文名:
- (2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid
- 英文别名:
- VELIFLAPON;DG 031;BAY 1005;Velifapon;BAY-X 1005;BAY-X-1005 >=98% (HPLC);ZEYYDOLCHFETHQ-JOCHJYFZSA-N;2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid;α-Cyclopentyl-4-(2-quinolinylmethoxy)-(R)-benzeneacetic acid;(αR)-α-Cyclopentyl-4-(2-quinolinylmethoxy)-benzeneacetic acid
- 中文名:
- BAY-X 1005
- 中文别名:
- 化合物 T13295
- CBNumber:
- CB41260812
- 分子式:
- C23H23NO3
- 分子量:
- 361.43
- MOL File:
- 128253-31-6.mol
|
|
|
BAY-X 1005化学性质
-
熔点:
-
169-171 °C
-
|
-
沸点:
-
555.4±40.0 °C(Predicted)
-
|
-
密度:
-
1.242±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMSO: soluble5mg/mL (clear solution)
-
|
-
形态:
-
powder
-
|
-
酸度系数(pKa):
-
4.47±0.10(Predicted)
-
|
-
颜色:
-
white to beige
-
|
BAY-X 1005性质、用途与生产工艺
Veliflapon (BAY X 1005; DG-031) 是一种具有口服活性的,选择性的 5-脂氧合酶激活蛋白 (FLAP) 抑制剂。Veliflapon 也是白三烯 B4 和 C4 合成的抑制剂。
Veliflapon (BAY X 1005; DG-031) effectively inhibits the synthesis of LTB4 in A23187-stimulated leukocytes from rats, mice and humans (IC
50
s of 0.026, 0.039 and 0.22 μM, respectively) as well as the formation of LTC4 (IC
50
of 0.021 μM) in mouse peritoneal macrophages stimulated with opsonized zymosan.
Veliflapon (BAY X 1005; DG-031; diet; 18.8 mg/kg/day for 16 weeks ) inhibits atherogenesis.
Veliflapon after topical (18 μg/ear) and oral (48.7 mg/kg) administration has antiedematous effects in the arachidonic acid-induced mouse ear inflammation test.
Veliflapon is potent (11.8 and 6.7 mg/kg p.o. at 1 and 5 hours, respectively) and has a long duration of action (ED
40
of 16 hours, 70 mg/kg p.o.) in the rat whole blood ex vivo leukotriene B4 inhibition assay.
Animal Model:
|
Female apoE/LDLR-DKO mouse model
|
Dosage:
|
18.8 mg/kg
|
Administration:
|
Diet; per day during 16 weeks
|
Result:
|
Inhibited atherogenesis.
|
BAY-X 1005
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-14165 | BAY-X 1005 Veliflapon | 128253-31-6 | 5mg | 2500元 |
2024/04/30 | HY-14165 | Veliflapon | | 10 mM * 1 mLin DMSO | 2750元 |
128253-31-6, BAY-X 1005 相关搜索:
- 化合物 T13295
- 128253-31-6
- VELIFLAPON
- BAY-X-1005 >=98% (HPLC)
- Benzeneacetic acid, α-cyclopentyl-4-(2-quinolinylmethoxy)-, (αR)-
- ZEYYDOLCHFETHQ-JOCHJYFZSA-N
- α-Cyclopentyl-4-(2-quinolinylmethoxy)-(R)-benzeneacetic acid
- (αR)-α-Cyclopentyl-4-(2-quinolinylmethoxy)-benzeneacetic acid
- Velifapon
- DG 031
- BAY 1005
- BAY-X 1005
- 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid
- (2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid