化合物R 59949
|
|
- CAS号:
- 120166-69-0
- 英文名:
- DIACYLGLYCEROL KINASE INHIBITOR II
- 英文别名:
- R59949;R-59949(R-59-949);DAG Kinase Inhibitor;DAG Kinase Inhibitor II;DIACYLGLYCEROL KINASE INHIBITOR II;Diacylglycerol Kinase Inhibitor II solid;DIACYLGLYCEROL KINASE INHIBITOR I (R59 949);DIACYLGLYCEROL KINASE INHIBITOR II (R 59 949);Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem;3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
- 中文名:
- 化合物R 59949
- 中文别名:
- 化合物R 59949;二酰甘油激酶抑制剂II;二酰基甘油激酶抑制剂II;二乙酰基甘油激酶抑制剂II;3-(2-(4-(双(4-氟苯基)亚甲基)哌啶-1-基)乙基)-2-硫代-2,3-二氢喹唑啉-4(1H)-酮
- CBNumber:
- CB4239260
- 分子式:
- C28H25F2N3OS
- 分子量:
- 489.58
- MOL File:
- 120166-69-0.mol
|
|
|
化合物R 59949化学性质
-
熔点:
-
228-230 °C
-
|
-
沸点:
-
637.1±65.0 °C(Predicted)
-
|
-
密度:
-
1.36±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
-20°C
-
|
-
溶解度:
-
0.1 M HCl: slightly soluble
-
|
-
形态:
-
solid
-
|
-
酸度系数(pKa):
-
11.24±0.20(Predicted)
-
|
-
颜色:
-
pale yellow
-
|
化合物R 59949性质、用途与生产工艺
R59949 是一种泛二酰甘油激酶 (DGK) 抑制剂,IC50 为 300 nM。R59949 强烈抑制 Ⅰ 型 DGKα 和 γ 的活性,中度减弱 Ⅱ 型 DGKθ 和 κ 的活性。R59949 通过提高内源性配体二酰甘油水平来激活蛋白激酶C (PKC)。
In the presence of R59949, vasopressin- as well as collagen-induced release reaction and aggregation was strongly increased, independently of the formation of arachidonate metabolites.
In THP‐1 monocytes, R59949 attenuates CCL2‐evoked Ca
2+
signalling with a half‐maximal concentration of 8.6 μM.
R59949 inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells.
化合物R 59949
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-108355 | R59949 | | 1 mg | 400元 |
2024/04/30 | HY-108355 | 化合物R 59949 R59949 | 120166-69-0 | 5mg | 924元 |
120166-69-0, 化合物R 59949 相关搜索:
- quinazolinone
- 喹啉酮
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- Diacylglycerol kinase (DAGK)
- Kinase/Phosphatase Biology
- Serine/Threonine Kinase Inhibitors
- C28H25F2N3OS
- 二酰甘油激酶抑制剂II
- 3-(2-(4-(双(4-氟苯基)亚甲基)哌啶-1-基)乙基)-2-硫代-2,3-二氢喹唑啉-4(1H)-酮
- 二乙酰基甘油激酶抑制剂II
- 化合物R 59949
- 二酰基甘油激酶抑制剂II
- 120166-69-0
- 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
- kinase,endogenous,PKC,plasma,platelet,diacylglycerol,Protein kinase C,Inhibitor,R59949,inhibit,ligand,membranes
- 3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
- R-59949(R-59-949)
- Diacylglycerol Kinase Inhibitor II solid
- 4(1H)-Quinazolinone, 3-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-
- Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem
- 3-[2-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1h)-quinazolinone
- DIACYLGLYCEROL KINASE INHIBITOR II (R 59 949)
- R59949
- 3-[2-(4-[BIS(4-FLUOROPHENYL)-METHYLENE)-1-PIPERIDINYL)ETHYL]-2,3-DIHYDRO-2-THIOXO-4[1H]-QUINAZOLINONE
- DAG Kinase Inhibitor
- DAG Kinase Inhibitor II
- 3-[2-[4-(bis(4-Fluorophenyl)Methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, R59949
- 3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
- R59949, 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
- DIACYLGLYCEROL KINASE INHIBITOR II
- DIACYLGLYCEROL KINASE INHIBITOR I (R59 949)