网站主页 >> CAS数据库列表 >> N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺
N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺
|
|
- CAS号:
- 209986-17-4
- 英文名:
- γ-Secretase Inhibitor XXI
- 英文别名:
- DuPont E;Compound E, gamma;-secretase inhibitor;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor XXI;CoMpound E (secretase inhibitor);Compound E (γ-Secretase Inhibitor XXI)
- 中文名:
- N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺
- 中文别名:
- 化合物 T3521;Γ-分泌酶抑制剂BZ;COMPOUND E (Γ-SECRETASE INHIBITOR XXI);(S)-2-(2-(3,5-二氟苯基)乙酰胺)-N-((S)-1-甲基-2-氧代-5-苯基-2,3-二氢-1H-苯并[E][1,4]二氮杂杂卓-3-基)丙酰胺;N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺
- CBNumber:
- CB42602844
- 分子式:
- C27H24F2N4O3
- 分子量:
- 490.5
- MOL File:
- 209986-17-4.mol
|
|
|
N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺化学性质
-
沸点:
-
778.6±60.0 °C(Predicted)
-
|
-
密度:
-
1.31
-
|
-
储存条件:
-
= -70C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Liquid
-
|
-
酸度系数(pKa):
-
12.54±0.40(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
-
敏感性:
-
Light Sensitive
-
|
N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺性质、用途与生产工艺
Compound E 是 γ-secretase 抑制剂。 Compound E 抑制 β-amyloid(40),β-amyloid(42),和Notch γ-分泌酶切割的 IC50 值分别为 0.24,0.37,0.32 nM。
IC50: 0.24 nM (β-amyloid(40)), 0.37 nM (β-amyloid(42)), 0.24 nM (Notch)
Compound E reduces the proliferation of T47D, and MCF-7 cell lines by less than 50% at a concentration of 50 μM.
N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺
上下游产品信息
上游原料
下游产品
N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺
生产厂家
209986-17-4, N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺 相关搜索:
- C27H24F2N4O3
- 化合物 T3521
- (S)-2-(2-(3,5-二氟苯基)乙酰胺)-N-((S)-1-甲基-2-氧代-5-苯基-2,3-二氢-1H-苯并[E][1,4]二氮杂杂卓-3-基)丙酰胺
- COMPOUND E (Γ-SECRETASE INHIBITOR XXI)
- Γ-分泌酶抑制剂BZ
- N-[(1S)-2-[[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟苯乙酰胺
- 209986-17-4
- -secretase inhibitor
- Compound E, gamma
- γ-Secretase Inhibitor XXI
- γ-Secretase Inhibitor BZ
- Benzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-
- Compound E (γ-Secretase Inhibitor XXI)
- BZ, γ-Secretase Inhibitor - Compound E
- StemSelect Compound E - CAS 209986-17-4 - Calbiochem
- (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
- (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
- γ-Secretase Inhibitor XXI
- γ-Secretase Inhibitor BZ
- g-Secretase Inhibitor XXI
- DuPont E
- CoMpound E (secretase inhibitor)
- N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide