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γ-Secretase Inhibitor XXI

CAS No.
209986-17-4
Chemical Name:
γ-Secretase Inhibitor XXI
Synonyms
DuPont E;Compound E, gamma;-secretase inhibitor;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor XXI;CoMpound E (secretase inhibitor);Compound E (γ-Secretase Inhibitor XXI)
CBNumber:
CB42602844
Molecular Formula:
C27H24F2N4O3
Molecular Weight:
490.5
MDL Number:
MOL File:
209986-17-4.mol
Last updated:2023-06-30 15:45:59

γ-Secretase Inhibitor XXI Properties

Boiling point 778.6±60.0 °C(Predicted)
Density 1.31
storage temp. = -70C
solubility Soluble in DMSO
form Liquid
pka 12.54±0.40(Predicted)
color White to off-white
Sensitive Light Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

γ-Secretase Inhibitor XXI price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 565790 γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem Thisg-secretaseinhibitor,CAS209986-17-4,isacell-permeable,potent,select 209986-17-4 500μg $345 2024-03-01 Buy
Sigma-Aldrich 565790 γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem 209986-17-4 1mg $445 2024-03-01 Buy
Sigma-Aldrich 5.30509 StemSelect Compound E - CAS 209986-17-4 - Calbiochem 209986-17-4 250μg $209 2024-03-01 Buy
Alfa Aesar J65131 Compound E 209986-17-4 0.5mg $307 2023-06-20 Buy
Cayman Chemical 15579 Compound E ≥98% 209986-17-4 500μg $189 2024-03-01 Buy
Product number Packaging Price Buy
565790 500μg $345 Buy
565790 1mg $445 Buy
5.30509 250μg $209 Buy
J65131 0.5mg $307 Buy
15579 500μg $189 Buy

γ-Secretase Inhibitor XXI Chemical Properties,Uses,Production

Uses

A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of -secretase and Notch processing

Definition

ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene.

storage

+4°C

γ-Secretase Inhibitor XXI Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 59)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32715 60
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Nextpeptide Inc
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InvivoChem
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LEAP CHEM CO., LTD.
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Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3136 58
Aladdin Scientific
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VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Shanghai Witofly Chemical Co.,Ltd sales@witofly.com China 2867 52
Shanghai SunSyn Pharmaceutical Co., Ltd. -2408801818 18621020637 sales@sunsynpharma.com China 293 55
N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide CoMpound E (secretase inhibitor) DuPont E g-Secretase Inhibitor XXI γ-Secretase Inhibitor BZ γ-Secretase Inhibitor XXI (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide StemSelect Compound E - CAS 209986-17-4 - Calbiochem BZ, γ-Secretase Inhibitor - Compound E Compound E (γ-Secretase Inhibitor XXI) Benzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro- γ-Secretase Inhibitor BZ γ-Secretase Inhibitor XXI Compound E, gamma -secretase inhibitor 209986-17-4 C27H24F2N4O3