GRI977143; GRI-977143
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- CAS号:
- 325850-81-5
- 英文名:
- 2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid
- 英文别名:
- GRI977143;GRI977143; GRI-977143;2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-benzoic acid;2-((3-(1,3-Dioxo-(1H)benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoic Acid;Benzoic acid, 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-;2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid;2-((3-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoic acid , GRI977143
- 中文名:
- GRI977143; GRI-977143
- 中文别名:
- 化合物 T22812;化合物GRI977143;GRI 977143,LPA2受体非脂质激动剂;2-((3-(1,3-二氧代-1H-苯并[DE]异喹啉-2(3H)-基)丙基)硫基)苯甲酸;2-[3-(1,3-二氧代-1H,3H-苯并[DE]异喹啉-2-基)-丙基磺酰基]-苯甲酸
- CBNumber:
- CB42652142
- 分子式:
- C22H17NO4S
- 分子量:
- 391.44
- MOL File:
- 325850-81-5.mol
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GRI977143; GRI-977143化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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形态:
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powder
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颜色:
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white to light brown
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GRI977143; GRI-977143性质、用途与生产工艺
GRI977143 是特异性的 LPA2 受体的激动剂，其EC50 值为3.3 μM。
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LPA
2
Receptor
3.3 μM (EC
50
)
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GRI977143 (10 μM, 24-72 h) is effective in reducing activation of caspases 3, 7, 8, and 9 and inhibits poly(ADP-ribose)polymerase 1 cleavage and DNA fragmentation in different extrinsic and intrinsic models of apoptosis.
GRI977143 is an effective stimulator of extracellular signal-regulated kinase 1/2 activation and promotes the assembly of a macromolecular signaling complex consisting of LPA2, Na+-H+ exchange regulatory factor 2, and thyroid receptor interacting protein 6.
Cell Proliferation Assay
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Cell Line:
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Vector- and LPA2-transduced MEF cells (2 × 10
4
)
[1]
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Concentration:
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10 μM.
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Incubation Time:
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24-72 h.
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Result:
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Did not cause a significant increase in vector cell proliferation except at 72 h (p < 0.05).
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Apoptosis Analysis.
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Cell Line:
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Doxorubicin-induced apoptotic signaling in vector-transduced or LPA2-transduced MEF.
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Concentration:
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10 μM.
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Incubation Time:
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24 h.
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Result:
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Reduced caspase 3 and 7 activation on LPA2-transduced MEF cells by 51 ± 3% and was approximately as potent as 3 μM LPA or OTP.
Protected against doxorubicin-induced apoptosis by inhibiting caspase 3, 7, 8, and 9 and reducing DNA fragmentation.
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GRI977143; GRI-977143
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100676 | GRI977143; GRI-977143
GRI977143 | | 10 mg | 2200元 |
| 2024/04/30 | HY-100676 | GRI977143; GRI-977143
GRI977143 | | 50 mg | 7800元 |
GRI977143; GRI-977143
生产厂家
325850-81-5, GRI977143; GRI-977143 相关搜索:
- 合成有机化合物配体
- 325850-80-5
- GRI 977143,LPA2受体非脂质激动剂
- 2-((3-(1,3-二氧代-1H-苯并[DE]异喹啉-2(3H)-基)丙基)硫基)苯甲酸
- 化合物GRI977143
- 化合物 T22812
- 2-[3-(1,3-二氧代-1H,3H-苯并[DE]异喹啉-2-基)-丙基磺酰基]-苯甲酸
- 325850-81-5
- 2-((3-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoic acid , GRI977143
- Benzoic acid, 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-
- GRI977143; GRI-977143
- 2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid
- GRI977143
- 2-[[3-(1,3-Dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-benzoic acid
- 2-((3-(1,3-Dioxo-(1H)benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoic Acid