网站主页 >> CAS数据库列表 >> 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
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- CAS号:
- 941575-71-9
- 英文名:
- 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
- 英文别名:
- BIP-135;BIP 135,BIP135;3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione;3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(3-benzofuranyl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-
- 中文名:
- 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
- 中文别名:
- 化合物BIP-135;化合物 T14613;3-(苯并呋喃-3-基)-4-(5-溴-1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮
- CBNumber:
- CB42695130
- 分子式:
- C21H13BrN2O3
- 分子量:
- 421.24
- MOL File:
- 941575-71-9.mol
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3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione化学性质
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沸点:
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643.5±55.0 °C(Predicted)
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密度:
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1?+-.0.1 g/cm3(Predicted)
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储存条件:
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room temp
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溶解度:
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DMSO: ≥15mg/mL
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形态:
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powder
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酸度系数(pKa):
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7.44±0.60(Predicted)
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颜色:
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light orange to dark orange
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3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione性质、用途与生产工艺
BIP-135 是一个高效、选择性的，ATP 竞争性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 作用的IC50 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。
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GSK-3α
16 nM (IC
50
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GSK-3β
21 nM (IC
50
)
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BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress.
Western Blot Analysis
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Cell Line:
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Human SMA fibroblasts
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Concentration:
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20 μM, 25 μM, 30 μM
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Incubation Time:
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72 hours
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Result:
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Led to a 7-fold increase in SMN levels at 25 μM.
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BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy.
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Animal Model:
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Male and female SMN2
+/+
, SMN2Δ7
+/+
, Smn
+/–
mice
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Dosage:
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75 mg/kg
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Administration:
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Intraperitoneal injection; daily; from postnatal day 0 to 21
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Result:
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Caused a modest extension in the median survival of SMA KO animals by two days.
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3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-111055 | 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
BIP-135 | 941575-71-9 | 1mg | 681元 |
| 2024/04/30 | HY-111055 | 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
BIP-135 | 941575-71-9 | 10mg | 2400元 |
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
生产厂家
941575-71-9, 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione 相关搜索:
- Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
- 化合物BIP-135
- 化合物 T14613
- 3-(苯并呋喃-3-基)-4-(5-溴-1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮
- 941575-71-9
- 1H-Pyrrole-2,5-dione, 3-(3-benzofuranyl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-
- BIP 135,BIP135
- 3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- BIP-135
- 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione