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ChemicalBook >> CAS DataBase List >>3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Structure
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione structure
CAS No.
941575-71-9
Chemical Name:
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
Synonyms
BIP-135;BIP 135,BIP135;BIP-135, 10 mM in DMSO;3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione;3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(3-benzofuranyl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-
CBNumber:
CB42695130
Molecular Formula:
C21H13BrN2O3
Molecular Weight:
421.24
MDL Number:
MFCD16495779
MOL File:
941575-71-9.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24
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3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Properties

Boiling point 643.5±55.0 °C(Predicted)
Density 1?+-.0.1 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥15mg/mL
form powder
pka 7.44±0.60(Predicted)
color light orange to dark orange

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0265 BIP-135 ≥95% (HPLC) 941575-71-9 5mg $118 2022-05-15 Buy
Sigma-Aldrich SML0265 BIP-135 ≥95% (HPLC) 941575-71-9 25mg $465 2022-05-15 Buy
TRC B685495 3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione 941575-71-9 100mg $835 2021-12-16 Buy
TRC B685495 3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione 941575-71-9 5mg $70 2021-12-16 Buy
TRC B685495 3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione 941575-71-9 10mg $115 2021-12-16 Buy
Product number Packaging Price Buy
SML0265 5mg $118 Buy
SML0265 25mg $465 Buy
B685495 100mg $835 Buy
B685495 5mg $70 Buy
B685495 10mg $115 Buy

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Chemical Properties,Uses,Production

Uses

Acts as a potent GSK-3 inhibitor which leads to therapeutic treatment of spinal muscular atrophy.

in vivo

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1].
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy[1].

Animal Model:Male and female SMN2+/+, SMN2Δ7+/+, Smn+/– mice[1]
Dosage:75 mg/kg
Administration:Intraperitoneal injection; daily; from postnatal day 0 to 21
Result:Caused a modest extension in the median survival of SMA KO animals by two days.

IC 50

GSK-3α: 16 nM (IC50); GSK-3β: 21 nM (IC50)

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Preparation Products And Raw materials

Raw materials

Preparation Products

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Suppliers

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
J & K SCIENTIFIC LTD. 18210857532 jkinfo@jkchemical.com China 96815 76
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979 info@tsbiochem.com China 8065 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7787 56
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2997 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9329 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
J & K SCIENTIFIC LTD. 76
Shanghai TaoSu Biochemical Technology Co., Ltd. 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58

View Lastest Price from 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BIP-135 pictures 2024-11-19 BIP-135
941575-71-9
 US $29.00-118.00 / mg 99.77% 10g TargetMol Chemicals Inc.
BIP-135 pictures 2024-11-19 BIP-135
941575-71-9
 US $29.00-118.00 / mg 99.77% 10g TargetMol Chemicals Inc.
  • BIP-135 pictures
  • BIP-135
    941575-71-9
  • US $29.00-118.00 / mg
  • 99.77%
  • TargetMol Chemicals Inc.
  • BIP-135 pictures
  • BIP-135
    941575-71-9
  • US $29.00-118.00 / mg
  • 99.77%
  • TargetMol Chemicals Inc.

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione Spectrum

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione(941575-71-9)1HNMR
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione BIP-135 3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione BIP 135,BIP135 1H-Pyrrole-2,5-dione, 3-(3-benzofuranyl)-4-(5-bromo-1-methyl-1H-indol-3-yl)- BIP-135, 10 mM in DMSO 941575-71-9 Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals