LCH-7749944
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- CAS号:
- 796888-12-5
- 英文名:
- LCH-7749944
- 英文别名:
- GNF-PF-2356;LCH-7749944;LCH-7749944， GNF-PF-2356;N2-(3-Methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine;2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]-;proliferation,cells,Inhibitor,c-Src,EGFR,inhibit,gastric,Apoptosis,LCH-7749944,PAK,cancer,PAK4,human,LCH7749944,p21 activated kinases,cyclin,LCH 7749944
- 中文名:
- LCH-7749944
- 中文别名:
- 化合物LCH-7749944;N2-(3-甲氧基苯基)-N4-((四氢呋喃-2-基)甲基)喹唑啉-2,4-二胺
- CBNumber:
- CB42731092
- 分子式:
- C20H22N4O2
- 分子量:
- 350.41
- MOL File:
- 796888-12-5.mol
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LCH-7749944化学性质
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沸点:
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580.0±58.0 °C(Predicted)
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密度:
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1.272±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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DMSO: 250 mg/mL (713.45 mM)
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酸度系数(pKa):
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7.68±0.30(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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LCH-7749944性质、用途与生产工艺
LCH-7749944 (GNF-PF-2356) 是一种有效的 PAK4 抑制剂，IC50 为 14.93 μM。LCH-7749944通过下调 PAK4/c-Src/EGFR/cyclin D1 途径有效抑制人胃癌细胞的增殖，并诱导凋亡 (apoptosis)。
LCH-7749944 (GNF-PF-2356; 5-50 μM; 24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.
LCH-7749944 (5-20 μM; 12-48 hours) induces apoptosis of SGC7901 cells.
LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase.
LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.
Cell Proliferation Assay
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Cell Line:
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MKN-1, BGC823, SGC7901 and MGC803 human gastric cancer cells
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Concentration:
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5, 10, 15, 20, 25, 30, 35, 40, 45, 50 μM
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Incubation Time:
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24 hours
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Result:
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Inhibited the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.
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Apoptosis Analysis
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Cell Line:
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SGC7901 cells
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Concentration:
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5, 10, 20 μM
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Incubation Time:
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12, 24, 48 hours
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Result:
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Induced apoptosis of SGC7901 cells.
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Cell Cycle Analysis
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Cell Line:
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SGC7901 cells
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Concentration:
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5, 10, 20 μM
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Incubation Time:
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12, 24, 48 hours
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Result:
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Prominently induced a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase.
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Western Blot Analysis
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Cell Line:
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SGC7901 cells
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Concentration:
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5, 10, 20, 30 μM
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Incubation Time:
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24 hours
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Result:
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Dramatically decreased levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.
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LCH-7749944
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-125035 | LCH-7749944
LCH-7749944 | 796888-12-5 | 5mg | 1980元 |
| 2024/11/08 | HY-125035 | LCH-7749944
LCH-7749944 | 796888-12-5 | 10mM * 1mLin DMSO | 2178元 |
796888-12-5, LCH-7749944 相关搜索:
- 抑制剂
- 药靶配体
- N2-(3-甲氧基苯基)-N4-((四氢呋喃-2-基)甲基)喹唑啉-2,4-二胺
- 化合物LCH-7749944
- 796888-12-5
- proliferation,cells,Inhibitor,c-Src,EGFR,inhibit,gastric,Apoptosis,LCH-7749944,PAK,cancer,PAK4,human,LCH7749944,p21 activated kinases,cyclin,LCH 7749944
- N2-(3-Methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine
- 2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]-
- LCH-7749944， GNF-PF-2356
- GNF-PF-2356
- LCH-7749944