LCH-7749944
| 中文名称 | LCH-7749944 |
|---|---|
| 中文同义词 | 化合物LCH-7749944;N2-(3-甲氧基苯基)-N4-((四氢呋喃-2-基)甲基)喹唑啉-2,4-二胺 |
| 英文名称 | LCH-7749944 |
| 英文同义词 | LCH-7749944;GNF-PF-2356;LCH-7749944， GNF-PF-2356;2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]-;N2-(3-Methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine;proliferation,cells,Inhibitor,c-Src,EGFR,inhibit,gastric,Apoptosis,LCH-7749944,PAK,cancer,PAK4,human,LCH7749944,p21 activated kinases,cyclin,LCH 7749944 |
| CAS号 | 796888-12-5 |
| 分子式 | C20H22N4O2 |
| 分子量 | 350.41 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 796888-12-5.mol |
| 结构式 |  |
LCH-7749944 性质
| 沸点 | 580.0±58.0 °C(Predicted) |
|---|---|
| 密度 | 1.272±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | 二甲基亚砜：250 mg/mL（713.45 mM） |
| 酸度系数(pKa) | 7.68±0.30(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
|
PAK4 14.93 μM (IC 50 ) |
LCH-7749944 (GNF-PF-2356; 5-50 μM; 24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.
LCH-7749944 (5-20 μM; 12-48 hours) induces apoptosis of SGC7901 cells.
LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase.
LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.
Cell Proliferation Assay
| Cell Line: | MKN-1, BGC823, SGC7901 and MGC803 human gastric cancer cells |
| Concentration: | 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner. |
Apoptosis Analysis
| Cell Line: | SGC7901 cells |
| Concentration: | 5, 10, 20 μM |
| Incubation Time: | 12, 24, 48 hours |
| Result: | Induced apoptosis of SGC7901 cells. |
Cell Cycle Analysis
| Cell Line: | SGC7901 cells |
| Concentration: | 5, 10, 20 μM |
| Incubation Time: | 12, 24, 48 hours |
| Result: | Prominently induced a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. |
Western Blot Analysis
| Cell Line: | SGC7901 cells |
| Concentration: | 5, 10, 20, 30 μM |
| Incubation Time: | 24 hours |
| Result: | Dramatically decreased levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-125035 | LCH-7749944 LCH-7749944 | 796888-12-5 | 5mg | 1980元 |
| 2024/11/08 | HY-125035 | LCH-7749944 LCH-7749944 | 796888-12-5 | 10mM * 1mLin DMSO | 2178元 |