IKK2抑制剂（LY2409881）
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- CAS号:
- 946518-60-1
- 英文名:
- LY2409881 trihydrochloride
- 英文别名:
- LY2409881;CS-1620;LY2409881 3HCl;LY-2409881 HC'l;LY2409881 triHCl;LY-2409881 ;LY 2409881;LY2409881 trihydrochloride;LY2409881 trihydrochloride USP/EP/BP;2-[5-chloro-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-N-cyclopropyl-1-benzothiophene-4-carboxamide;LY2409881 trihydrochloride,Inhibitor,IκB kinase,Apoptosis,IKK,inhibit,I kappa B kinase,LY-2409881 trihydrochloride
- 中文名:
- IKK2抑制剂（LY2409881）
- 中文别名:
- LY2409881三盐酸盐;IKK2抑制剂(LY2409881);化合物LY2409881 TRIHYDROCHLORIDE;2-(5-氯-2-((3-(4-甲基哌嗪-1-基)丙基)氨基)嘧啶-4-基)-N-环丙基苯并[B]噻吩-4-羧酰胺 三盐酸盐;2-[5-氯-2-[[3-(4-甲基-1-哌嗪基)丙基]氨基]-4-嘧啶基]-N-环丙基-苯并[B]噻吩-4-甲酰胺三盐酸盐
- CBNumber:
- CB42743099
- 分子式:
- C24H30Cl2N6OS
- 分子量:
- 521.51
- MOL File:
- 946518-60-1.mol
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IKK2抑制剂（LY2409881）化学性质
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储存条件:
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Store at -20°C
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溶解度:
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≥59.4 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
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形态:
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solid
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颜色:
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Light yellow to yellow
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IKK2抑制剂（LY2409881）性质、用途与生产工艺
LY2409881 是一种有效的选择性 IKK2 抑制剂，IC50 为 30 nM，选择性比IKK1和其他常见激酶高10倍多。
LY2409881 inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth.
In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) significantly inhibits the tumor growth.
IKK2抑制剂（LY2409881）
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/11/08 | HY-B0788A | IKK2抑制剂（LY2409881）
LY2409881 trihydrochloride | 946518-60-1 | 5mg | 800元 |
| 2024/11/08 | HY-B0788A | IKK2抑制剂（LY2409881）
LY2409881 trihydrochloride | 946518-60-1 | 10mM * 1mLin DMSO | 1046元 |
946518-60-1, IKK2抑制剂（LY2409881） 相关搜索:
- Inhibitors
- 抑制剂
- 药靶配体
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- C24H32Cl4N6OS
- C24H29ClN6OS3HCl
- 2-(5-氯-2-((3-(4-甲基哌嗪-1-基)丙基)氨基)嘧啶-4-基)-N-环丙基苯并[B]噻吩-4-羧酰胺 三盐酸盐
- 化合物LY2409881 TRIHYDROCHLORIDE
- LY2409881三盐酸盐
- IKK2抑制剂(LY2409881)
- 2-[5-氯-2-[[3-(4-甲基-1-哌嗪基)丙基]氨基]-4-嘧啶基]-N-环丙基-苯并[B]噻吩-4-甲酰胺三盐酸盐
- 946518-60-1
- LY2409881 trihydrochloride,Inhibitor,IκB kinase,Apoptosis,IKK,inhibit,I kappa B kinase,LY-2409881 trihydrochloride
- LY2409881
- LY2409881 3HCl
- CS-1620
- LY-2409881 HC'l
- LY-2409881 ;LY 2409881
- 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride
- 2-[5-chloro-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-N-cyclopropyl-1-benzothiophene-4-carboxamide
- LY2409881 trihydrochloride USP/EP/BP
- LY2409881 triHCl
- 2-[5-Chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride
- 2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride
- LY2409881 trihydrochloride